NCT03808090

Obesity and Endogenous Oxalate Synthesis

Completed NA Results posted Last updated 19 September 2024

What this trial tests

NA trial testing Normal Individuals in Obesity in 58 participants. Completed in 31 July 2024.

Timeline

1 January 2013

Primary endpoint
1 July 2023

31 July 2024

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	58
Start date	1 January 2013
Primary completion	1 July 2023
Estimated completion	31 July 2024
Sites	1 location across United States

Drugs / interventions tested

• Normal Individuals

Conditions studied

• Obesity — all drugs for Obesity →

Sponsor

University of Alabama at Birmingham

Who can join

Adults 19 to 70, any sex, with Obesity. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Urinary Oxalate Excretion Primary · 3 days on the fixed diet

Mean Urinary oxalate excretion from three 24 hour urine collections on the fixed diet (mg/day)

Group	Value	95% CI
Normal Individuals	24	± 10

Urinary Glycolate Excretion Secondary · 3 days on fixed diet

mean of three 24-hr urinary glycolate collected on the fixed diet (mg/day)

Group	Value	95% CI
Normal Individuals	32	± 14

Urinary Creatinine Excretion Secondary · 3 days on the fixed diet

mean of there 24hr urinary creatinine excretion on the fixed diet ( g/day)

Group	Value	95% CI
Normal Individuals	1.47	± 0.58

Sponsor's own description

The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones.

The study will recruit adult participants without history of kidney stones. Participants will

* Ingest fixed diets containing low amounts of oxalate for 4 days
* Collect 24-hr urine samples during the fixed diet

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.