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NCT03805282
Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence
Phase 3 trial testing Lidocaine in Cough in 132 participants. Status unknown.
15 December 2019
Quick facts
| Lead sponsor | Brasilia University Hospital |
|---|---|
| Phase | Phase 3 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 132 |
| Start date | 1 March 2018 |
| Primary completion | 15 December 2019 |
| Estimated completion | 31 December 2019 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Lidocaine — full drug profile →
Conditions studied
- Cough — all drugs for Cough →
Sponsor
Brasilia University Hospital
Who can join
Adults 18 to 120, any sex, with Cough. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: Although inflating tracheal cuff using lidocaine is effective for cough suppression, it may pressure tracheal cuff too much. Intravenous continuous infusion of lidocaine has emerged recently for most general anesthesia in the context of opioid-sparing anesthesia for cancer, but the 95% effective dose (ED95) for cough suppression during anesthesia emergence is not determined yet. Objective: the objectives of this study are to determine the ED95 of continuous infusion lidocaine for suppressing cough reflex during extubation by sex and age group.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03805282
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT06923787 — Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patient · Phase 2 · recruiting
- NCT07355049 — The Effect of Dexmedetomidine Versus Lidocaine on Emergence Agitation. · NA · not yet recruiting
Other recruiting trials for Cough
Currently open trials in the same condition.
- NCT07171099 — Efficacy and Safety of Rengalin in the Treatment of ARVI Cough in Children · Phase 3 · recruiting
- NCT06999577 — The Mechanism Versus PPI Trial · Phase 4 · recruiting
- NCT06979141 — Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia · Phase 3 · recruiting
- NCT06918756 — Development of a Cough Control Questionnaire (CCQ) · recruiting
- NCT06878209 — Cough and Hemorrhoids · recruiting
Other Brasilia University Hospital trials
Trials by the same sponsor.
- NCT04291794 — Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion · Phase 4 · unknown
- NCT04288466 — Gastric Emptying of Maltodextrin Solution in Elderly and in Adults · NA · unknown
- NCT03725228 — Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial · Phase 4 · completed
- NCT03595319 — Median Sevoflurane Concentration for Hypotension Between Young and Elderlypatients: Adaptive Clinical Trial · Phase 4 · unknown
- NCT03280706 — Gastric Emptying During Labor at Term: Non-inferiority Clinical Trial · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03805282 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brasilia University Hospital
- Last refreshed: 15 January 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03805282.
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