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NCT03796039

Stand if You Can: A Standing Intervention in Long Term Care

Completed NA Results posted Last updated 27 June 2023
What this trial tests

NA trial testing Standing in Frailty in 97 participants. Completed in 15 July 2020.

Timeline
1 April 2019
Primary endpoint
23 January 2020
15 July 2020

Quick facts

Lead sponsorUniversity of New Brunswick
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposesupportive care
Enrollment97
Start date1 April 2019
Primary completion23 January 2020
Estimated completion15 July 2020
Sites1 location across Canada

Drugs / interventions tested

Conditions studied

Sponsor

University of New Brunswick

Who can join

Eligibility, any sex, with Frailty or Sedentary Behavior. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Changes in Walking Speed Primary · Pre and post intervention testing

Measured by the 10m walking speed test

Pre
GroupValue95% CI
Standing and Social Intervention0.34± 0.17
Control Group0.43± 0.20
Post
GroupValue95% CI
Standing and Social Intervention0.35± 0.20
Control Group0.40± 0.20
Change in Leg Strength Secondary · Pre-Post Testing (following the 5 month intervention)

Using hand-held dynamometer to quantify leg strength through knee extension

Pre
GroupValue95% CI
Standing and Social Intervention9.48± 5.95
Control Group7.87± 5.42
Post
GroupValue95% CI
Standing and Social Intervention9.15± 5.25
Control Group7.28± 4.90
Change Lower Limb Power Secondary · Pre-Post Testing (following the 5 month intervention)

Using the 30second sit-stand test following senior fitness test protocol

Pre
GroupValue95% CI
Standing and Social Intervention0.74± 1.84
Control Group0.89± 2.34
Post
GroupValue95% CI
Standing and Social Intervention0.71± 1.81
Control Group1.1± 2.82
Change in Anxiety Symptoms Secondary · Pre-Post Testing (following the 5 month intervention)

The Geriatric Anxiety Inventory (Scale 0-20). A low score means a better outcome.

Pre
GroupValue95% CI
Standing and Social Intervention6.1± 7.2
Control Group6.6± 6.0
Post
GroupValue95% CI
Standing and Social Intervention6.7± 7.1
Control Group6.6± 6.1
Depression Secondary · Pre-Post Testing (following the 5 month intervention)

Geriatric Depression Scale Short Form (0-15 scale). Lower score is better outcome.

Pre
GroupValue95% CI
Standing and Social Intervention5.1± 3.2
Control Group4.9± 3.5
Post
GroupValue95% CI
Standing and Social Intervention5.5± 4.0
Control Group4.5± 2.9
Loneliness Secondary · Pre-Post Testing (following the 5 month intervention)

Loneliness was measured using the UCLA Loneliness Scale (20-80). A low score indicates a better outcome

Pre
GroupValue95% CI
Standing and Social Intervention42.3± 12.0
Control Group39.7± 12.6
Post
GroupValue95% CI
Standing and Social Intervention38.7± 12.4
Control Group33.8± 11.2
Fall Efficacy Secondary · Pre-Post Testing (following the 5 month intervention)

Falls Efficacy Scale-International Questionnaire (16-64 scale). Low score indicates a better score

Pre
GroupValue95% CI
Standing and Social Intervention36.7± 13.2
Control Group31.0± 12.8
Post
GroupValue95% CI
Standing and Social Intervention41.3± 17.4
Control Group39.0± 11.8
Metabolic Profile - Triglycerides Secondary · Pre-Post Testing (before and following the 5 month intervention).

Capillary blood analyzed with a cardiochek device. Blood collected via a finger prick and analyzed with a cardiochek device. Note that Total Cholesterol, HDL, Triglycerides, LDL and Glucose were all measured using the cardiochek device.

Pre
GroupValue95% CI
Standing and Social Intervention1.79± 1.30
Control Group1.21± 0.45
Post
GroupValue95% CI
Standing and Social Intervention1.48± 0.74
Control Group1.47± 0.82
Metabolic Profile - High Density Lipoprotein Cholesterol Secondary · Pre and post testing (before and after the 5-month intervention)

High Density Lipoprotein (HDL) cholesterol was analyzed using the CardioChek Professional Analyzer system (PTS Diagnostics, Whitestown, Indiana, USA). A finger prick was conducted using a single use lancet and approximately 60 µL of whole blood was collected for this test.

Pre
GroupValue95% CI
Standing and Social Intervention1.37± 1.52
Control Group1.33± 0.51
Post
GroupValue95% CI
Standing and Social Intervention1.27± 0.44
Control Group1.17± 0.57
Metabolic Profile - Low Density Lipoprotein Cholesterol Secondary · Pre-Post intervention (before and after 5-month intervention)

Low-density lipoprotein was assessed using a CardioChek Professional Analyzer system (PTS Diagnostics, Whitestown, Indiana, USA).

Pre
GroupValue95% CI
Standing and Social Intervention2.40± 1.63
Control Group2.91± 1.42
Post
GroupValue95% CI
Standing and Social Intervention2.19± 1.21
Control Group2.72± 1.56
Metabolic Profile - Blood Glucose Secondary · Pre-Post Intervention (before and after 5-month intervention)

Fasted blood glucose was analyzed using a CardioChek Professional Analyzer system (PTS Diagnostics, Whitestown, Indiana, USA).

Pre
GroupValue95% CI
Standing and Social Intervention5.96± 2.38
Control Group5.43± 1.95
Post
GroupValue95% CI
Standing and Social Intervention6.08± 2.29
Control Group5.47± 1.77

Adverse events — posted to ClinicalTrials.gov

Time frame: During trial (5 months). Reporting threshold: 2%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Standing and Social Intervention
Serious: 0/50 (0%)
Deaths: 0/50
Control Group
Serious: 0/47 (0%)
Deaths: 0/47
Other adverse events (1 terms — click to expand)

ReactionSystemStanding and Social Interv…Control Group
FallInjury, poisoning and procedural complications

Data from ClinicalTrials.gov NCT03796039 adverse events section.

Sponsor's own description

It is currently unknown if reducing sitting time, an activity that is highly prevalent in frail older adults living in long term care (LTC) facilities, is associated with an improvement in physical capacity such as walking speed. Simple tasks such as walking speed is associated with important outcomes for residents in LTC such as autonomy and hospitalization. The investigators hypothesize that standing an additional 100 minutes per week for 5 months will result in a clinically meaningful improvement in walking speed (0.1m/sec) in LTC residents compared to residents receiving a sitting social activity.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Stand if you can- A parallel, superiority cluster randomized controlled trial to improve gait speed for long term care residents.
    Cooling K, Bouchard DR, Gallibois M, Hebert J, et al · · 2025 · PMID 40469490 · DOI 10.1016/j.jarlif.2025.100015

Verify or expand the search:

Other trials of Standing

Trials testing the same drug.

Other recruiting trials for Frailty

Currently open trials in the same condition.

Other University of New Brunswick trials

Trials by the same sponsor.

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