NCT03213717: EBU

Effect of Body Weight Loading on Urinary Electrolyte Excretion

Completed NA Last updated 2 April 2025

What this trial tests

NA trial testing Heavy Casall HIT weight vest in Obesity in 15 participants. Completed in 4 July 2017.

Timeline

13 June 2017

Primary endpoint
4 July 2017

4 July 2017

Quick facts

Lead sponsor	Göteborg University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	15
Start date	13 June 2017
Primary completion	4 July 2017
Estimated completion	4 July 2017
Sites	1 location across Sweden

Drugs / interventions tested

• Heavy Casall HIT weight vest
• Standing
• Water load
• Sitting
• Light Casall HIT weight vest

Conditions studied

• Obesity — all drugs for Obesity →
• Edema — all drugs for Edema →

Sponsor

Göteborg University

Who can join

18 and older, any sex, with Obesity or Edema. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Title: Effect of body weight loading on urinary electrolyte excretion

Swedish Title: Effekt av belastning på utsöndring av elektrolyter

Study period: Q2-Q3 2017

Study site: The study will be performed at the Institution for Neurology and Physiology, Sahlgrenska Academy, University of Gothenburg. Principal Investigator is John-Olov Jansson, MD, PhD, Professor at Institute of Neuroscience and Physiology, University of Gothenburg

Background and study design: Weight reduction can be obtained by decreased appetite or increased metabolism. However, acute weight loss can also be obtained by loss of fluids - for example by increased urinary loss of fluid and salts, so called elctrolytes. Preliminary results from a laboratory lesson for the Master of Science in Medicine program at University of Gothenburg suggest that carrying a 10 kg weight vest could increase urinary excretion of Na+, K+ and Cl-. The purpose of this study is to investigate this further in a more controlled research setting. If confirmed, the results could potentially contribute to the development of potent diuretics or obesity medicines.

The study will include 15 healthy volunteers and consist of three study days with about one week between each study day. The study subjects will go through a different study procedure each study day, and a randomized cross-over study design will be used to determine which procedure each day.

Procedure 1: Wearing a weight vest with 10 % of body weight standing for seven hours. The study subject is allowed to sit for 10 minutes each hour. The reason for this is that it has been considered that the effect may be transmitted by weight loading of the lower extremities.

Procedure 2: Wearing a weight vest with 1 % of body weight standing for seven hours, as a control for procedure 1, with lower loading. The study subject is allowed to sit for 10 minutes each hour.

Procedure 3: Wearing a weight vest with 1 % of body weight sitting for seven hours. This is a procedure with even less loading of the lower extremities than during procedure 2.

Urine- and blood samples, as well as heart rate and blood pressure measurements, will be collected during the study days and analyzed in order to address the primary and secondary objectives of the study.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.