NCT03792373

Hospital Ederly Life Program for Surgical Patients

Status unknown Last updated 3 January 2019

What this trial tests

trial in To Investigate the Mortality of the Frailty Patients in 300 participants. Status unknown.

Timeline

1 December 2018

Primary endpoint
30 May 2019

30 December 2019

Quick facts

Lead sponsor	Zhongda Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	300
Start date	1 December 2018
Primary completion	30 May 2019
Estimated completion	30 December 2019
Sites	1 location across China

Conditions studied

• To Investigate the Mortality of the Frailty Patients — all drugs for To Investigate the Mortality of the Frailty Patients →

Sponsor

Zhongda Hospital

Who can join

Adults 65 to 100, any sex, with To Investigate the Mortality of the Frailty Patients. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Frailty is the clinically recognizable medical condition, also called syndrome or phenotype, that is, the result of processes leading to an increased vulnerability for serious deteriorations in health and the diminished ability to cope with physical stressors. Recently, frailty has emerged as a significant risk factor for adverse postoperative outcomes. It is related to declines in energy, strength, and function as well as to an increased inflammatory state, including elevated levels of interleukin 6 (IL-6), C-reactive protein (CRP), and anelevated white blood cell count . Frailty, as defined Frailty, as defined in the landmark paper by Fried, included at least three of five of the following criteria: unintentional loss of weight, low physical activity, low energy, low grip strength, and a slowed walking speed. Since then, various frailty scoring lists have been designed to optimize the predictive value. One of these is the Edmonton Frail Scale (EFS), an instrument that can be assessed quickly, using only a simple questionnaire which usually does not require more than five minutes to be completed and which covers most domains of functioning, making it easy and fast to get a reliable impression of the degree of frailty.The aim of this study was to determine which factors,with emphasis on frailty, significantly influence postoperative outcome after elective noncardiac surgery as measured by the Comprehensive Complication Index (CCI).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients.
   Mao M, Wang LY, Zhu LY, Wang F, et al · · 2022 · cited 13× · PMID 35982410 · DOI 10.1186/s12877-022-03367-y
2. Frailty is an independent risk factor of one-year mortality after elective orthopedic surgery: a prospective cohort study.
   Sun X, Shen Y, Ji M, Feng S, et al · · 2021 · cited 10× · PMID 33638946 · DOI 10.18632/aging.202576