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NCT03787875
Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid
trial testing periodontal treatment in Periodontal Diseases in 40 participants. Completed in 6 November 2016.
5 June 2016
Quick facts
| Lead sponsor | University of Valencia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 2 February 2016 |
| Primary completion | 5 June 2016 |
| Estimated completion | 6 November 2016 |
Drugs / interventions tested
- periodontal treatment
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Biomarkers — all drugs for Biomarkers →
- Bone Resorption — all drugs for Bone Resorption →
Sponsor
University of Valencia
Who can join
Adults 40 to 60, any sex, with Periodontal Diseases or Biomarkers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objectives: Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG). The aim of this study was to evaluate changes in the RANKL/OPG ratio in crevicular fluid after periodontal treatment. Material and methods: A total of 15 patients with periodontitis were included in the study group. Samples were collected from an area with active periodontitis and a healthy area. The RANKL and OPG levels were measured before and after periodontal scaling and root planing (SRP) treatment. The study group was compared to the control group, which included 10 patients without periodontitis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of periodontal treatment on the RANKL/OPG ratio in crevicular fluid.
López Roldán A, García Giménez JL, Alpiste Illueca F. · · 2020 · cited 25× · PMID 31986169 · DOI 10.1371/journal.pone.0227757
Verify or expand the search:
- PubMed search for NCT03787875
- Europe PMC full search
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Related trials
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Currently open trials in the same condition.
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Other University of Valencia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03787875 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Valencia
- Last refreshed: 26 December 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03787875.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing