NCT03786185: MusicPlast

Neuroplasticity of Multisensory Cortical Areas Induced by Musical Training: a Translational Approach (MusicPlast)

Status unknown NA Last updated 1 March 2024

What this trial tests

NA trial testing MusicPlast in Dyslexia in 75 participants. Status unknown.

Timeline

2 August 2018

Primary endpoint
31 December 2024

31 December 2024

Quick facts

Lead sponsor	Aristotle University Of Thessaloniki
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	75
Start date	2 August 2018
Primary completion	31 December 2024
Estimated completion	31 December 2024
Sites	1 location across Greece

Drugs / interventions tested

• MusicPlast
• MusicPlast Control

Conditions studied

• Dyslexia — all drugs for Dyslexia →
• Aging Problems — all drugs for Aging Problems →

Sponsor

Aristotle University Of Thessaloniki

Who can join

Adults 12 to 100, any sex, with Dyslexia or Aging Problems. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Exploiting recent methodological advancements, several neuroimaging studies suggested that multisensory integration emerges from a dynamic interplay of distributed regions operating in large-scale networks. Nonetheless, the cortical structures and neuronal networks underlying the development of multisensory perception and plasticity, throughout the life span, have not yet been studied in detail. A special case of multisensory training is musical training, which utilizes stimulus' structural complexity, as well as the emotional drive that music is generating to the subjects, in order to induce augmented neuroplastic effects.

Retaining the extensive neuroplastic characteristics of music training, MUSICPLAST will develop, investigate and deliver a computer provided multisensory training protocol that aims to induce neuroplastic changes in frontotemporal cortical areas. More specifically, the goal of the proposed project is threefold: (a) The in-depth understanding and modeling of the developmental trajectory of the cortical networks underlying multisensory perception, (b) the modeling of the developmental trajectory of the cortical networks underlying multisensory plasticity throughout the life span of healthy subjects; and (c) the translation of this model in a computer provided multisensory training intervention protocol, which will cause beneficial neuroplastic changes in pathological populations. Electroencephalographic, behavioral and neuropsychological measurements, and advanced data analysis procedures, pre- and post the training application are going to be employed in order to evaluate the resulting neuroplasticity holistically. The proposed protocol will also be translated into an applied intervention for 2 groups of pathological population, for which there are strong evidence that a multisensory cognitive training based on music may provide beneficial neuroplastic changes: elderlies suffering from mild cognitive Impairment and adolescents with dyslexia.

The project is performed in the Laboratory of Medical Physics of the Aristotle University of Thessaloniki. It takes advantage of the extensive background of the laboratory in music and neuroscience, in multisensory perception and in applications that translate basic neuroscientific knowledge into computer based interventions for young adults and elderlies, building up a solid neuroscientific ground on which multidisciplinary characteristics of the project stand.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Multisensory vs. unisensory learning: how they shape effective connectivity networks subserving unimodal and multimodal integration.
   Porfyri I, Paraskevopoulos E, Anagnostopoulou A, Styliadis C, et al · · 2025 · PMID 41048358 · DOI 10.3389/fnins.2025.1641862