Last reviewed · How we verify
NCT03785158: MIND
MIND After Surgery
NA trial testing Liquid Melatonin in Post-operative Delirium in 88 participants. Completed in 5 July 2025.
5 July 2025
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | supportive care |
| Enrollment | 88 |
| Start date | 14 September 2021 |
| Primary completion | 5 July 2025 |
| Estimated completion | 5 July 2025 |
| Sites | 2 locations across Canada |
Drugs / interventions tested
- Liquid Melatonin
- Placebo
Conditions studied
- Post-operative Delirium — all drugs for Post-operative Delirium →
- Major Non-cardiac Surgery — all drugs for Major Non-cardiac Surgery →
Sponsor
McMaster University
Who can join
65 and older, any sex, with Post-operative Delirium or Major Non-cardiac Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Delirium is the most common neurological adverse outcome in elderly surgical patients. It is associated with an increased mortality and morbidity, including need for prolonged hospital stay and institutional care. Despite this, there are no effective preventive strategies. Melatonin is a hormone released from the pineal gland. It is used to improve sleep quality and to treat jet lag. Small studies have suggested that it can decrease the chances of delirium. Since the existing literature is small and uncertain, it is important to test its benefit in a large sample to help guide clinicians. This proposed trial is aimed at testing assessing the feasibility of a large, multi-center, randomized control trial to decrease the incidence of postoperative delirium.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study.
Khaled M, Chui J, Ewusie J, Agzarian J, et al · · 2025 · cited 2× · PMID 39998812 · DOI 10.1097/md.0000000000041615
Verify or expand the search:
- PubMed search for NCT03785158
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other McMaster University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03785158 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 12 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03785158.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing