NCT03781544 (OPIOVASC) is a Phase 4 clinical trial of Tramadol in Osteoarthritis of Multiple Joints of Ankle or Foot, sponsored by University of Zurich.

Who is sponsoring NCT03781544?

NCT03781544 is sponsored by University of Zurich.

What drugs are being tested in NCT03781544?

Interventions in NCT03781544: Tramadol, Paracetamol, Diclofenac.

What condition does NCT03781544 study?

NCT03781544 studies Osteoarthritis of Multiple Joints of Ankle or Foot, Healthy.

Is NCT03781544 still recruiting?

NCT03781544 is currently recruiting now. Last updated 17 May 2024.

Last reviewed 2024-05-17 · How we verify

NCT03781544: OPIOVASC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Recruiting now Phase 4 Last updated 17 May 2024

What this trial tests

Phase 4 trial testing Tramadol in Osteoarthritis of Multiple Joints of Ankle or Foot in 90 participants. Currently enrolling.

Timeline

1 January 2019

Primary endpoint
31 July 2025

31 December 2025

Quick facts

Lead sponsor	University of Zurich
Phase	Phase 4
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	90
Start date	1 January 2019
Primary completion	31 July 2025
Estimated completion	31 December 2025
Sites	1 location across Switzerland

Drugs / interventions tested

Tramadol (tramadol) — full drug profile →
Paracetamol (Paracetamol) — full drug profile →
Diclofenac (DICLOFENAC) — full drug profile →

Conditions studied

Osteoarthritis of Multiple Joints of Ankle or Foot — all drugs for Osteoarthritis of Multiple Joints of Ankle or Foot →
Healthy — all drugs for Healthy →

Sponsor

University of Zurich

Who can join

18 and older, any sex, with Osteoarthritis of Multiple Joints of Ankle or Foot or Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy subjects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs.
Chen Y, Sun H, Yao X, Yu Y, et al · · 2021 · cited 9× · PMID 34783870 · DOI 10.1007/s00018-021-03983-8

Verify or expand the search:

Other trials of Tramadol

Trials testing the same drug.

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NCT07332572 — COMPARISON OF INTRAVENOUS DEXMEDETOMEDINE AND TRAMADOL FOR POST OPERATIVE SHIVERING AFTER SPINAL ANESTHESIA FOR CAESAREA · Phase 4 · completed
NCT07110051 — Nalbuphine Versus Tramadol on Post Operative Analgesia in Abdominal Surgery on Pediatric Cancer Patient · NA · recruiting

Other University of Zurich trials

Trials by the same sponsor.

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NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03781544 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 17 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03781544.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing