NCT03767127

Oxygen Extraction-guided Transfusion in Critically Ill Patients

Completed Last updated 21 November 2019

What this trial tests

trial in Anemia in 177 participants. Completed in 30 December 2018.

Timeline

1 July 2017

Primary endpoint
1 October 2018

30 December 2018

Quick facts

Lead sponsor	Università degli Studi di Ferrara
Status	Completed
Study type	OBSERVATIONAL
Enrollment	177
Start date	1 July 2017
Primary completion	1 October 2018
Estimated completion	30 December 2018
Sites	1 location across Italy

Conditions studied

• Anemia — all drugs for Anemia →
• Critical Illness — all drugs for Critical Illness →

Sponsor

Università degli Studi di Ferrara — full company profile →

Who can join

18 and older, any sex, with Anemia or Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in this field have usually been based on transfusion thresholds. In the "TRICC" Trial, patients assigned to a restrictive transfusion strategy (transfusion if Hb\<7 g/dL) had similar mortality to patients transfused if Hb\<10 g/dL. Notably, none of the large RCT tried to focus on a personalize RBC transfusion protocol, i.e. a transfusion protocol which address the individual need for transfusion basing on physiological approach. We therefore hypothesized that patients with high extraction of oxygen could benefit more of RBCs transfusion regardless their hemoglobin levels.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Using arterial-venous oxygen difference to guide red blood cell transfusion strategy.
   Fogagnolo A, Taccone FS, Vincent JL, Benetto G, et al · · 2020 · cited 21× · PMID 32312299 · DOI 10.1186/s13054-020-2827-5