NCT03764020 (MRCTEBP) is a Phase 3 clinical trial of Melatonin/experimental in Elevated Blood Pressure, sponsored by Tehran University of Medical Sciences.

Who is sponsoring NCT03764020?

NCT03764020 is sponsored by Tehran University of Medical Sciences.

What drugs are being tested in NCT03764020?

Interventions in NCT03764020: Placebo oral capsule/placebo comparator, Melatonin/experimental.

What condition does NCT03764020 study?

NCT03764020 studies Elevated Blood Pressure.

Is NCT03764020 still recruiting?

NCT03764020 is currently status unknown. Last updated 10 April 2019.

Last reviewed 2019-04-10 · How we verify

NCT03764020: MRCTEBP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Trial of Oral Melatonin in Elevated Blood Pressure

Status unknown Phase 3 Last updated 10 April 2019

What this trial tests

Phase 3 trial testing Placebo oral capsule/placebo comparator in Elevated Blood Pressure in 320 participants. Status unknown.

Timeline

1 June 2019

Primary endpoint
1 November 2019

1 December 2019

Quick facts

Lead sponsor	Tehran University of Medical Sciences
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	320
Start date	1 June 2019
Primary completion	1 November 2019
Estimated completion	1 December 2019

Drugs / interventions tested

Placebo oral capsule/placebo comparator
Melatonin/experimental — full drug profile →

Conditions studied

Elevated Blood Pressure — all drugs for Elevated Blood Pressure →

Sponsor

Tehran University of Medical Sciences

Who can join

Adults 30 to 60, any sex, with Elevated Blood Pressure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Since, lowering blood pressure (BP) in elevated blood pressure individuals represents an excellent opportunity to for primary prevention of hypertension (HTN). Therefore, it is planned to use a safe treatment option - oral melatonin supplementation - associated with lifestyle interventions according to the American college of cardiology/American heart association (ACC/AHA) 2013 guideline in elevated blood pressure individuals to mitigate systolic and diastolic BP and ultimately, to prevent the development of HTN. Hypothesis: Melatonin therapy can lower the systolic and diastolic BP of elevated blood pressure individuals Melatonin can attenuate levels of circulatory biomarkers of Hs- CRP, Cholesterol, LDL-c and triglyceride

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease.
Huang X, Zeng Z, Li S, Xie Y, et al · · 2022 · cited 14× · PMID 36559254 · DOI 10.3390/pharmaceutics14122760

Verify or expand the search:

Other recruiting trials for Elevated Blood Pressure

Currently open trials in the same condition.

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NCT04766424 — Sleep Technology Intervention to Target Cardiometabolic Health · NA · active not recruiting

Other Tehran University of Medical Sciences trials

Trials by the same sponsor.

NCT07305883 — Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain · Phase 3 · not yet recruiting
NCT06876194 — The Effect of Music on the Sedation Quality Among Children in the Emergency Department. · Phase 3 · completed
NCT06721273 — Iodine Supplementation and Fertility Parameters · NA · not yet recruiting
NCT07014397 — Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth · NA · completed
NCT06615934 — Effects of Aerobic and Resistance Exercises on Inpatients Liver Transplantation Recipients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03764020 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tehran University of Medical Sciences
Last refreshed: 10 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03764020.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing