NCT03756948: VETLT

Viscoelastic Tests-Guided Therapy In Liver Transplantation

Completed NA Last updated 28 November 2018

What this trial tests

NA trial testing Usual Care in Liver Transplant; Complications in 237 participants. Completed in 1 January 2018.

Timeline

1 January 2007

Primary endpoint
30 October 2015

1 January 2018

Quick facts

Lead sponsor	Hospital Israelita Albert Einstein
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	237
Start date	1 January 2007
Primary completion	30 October 2015
Estimated completion	1 January 2018

Drugs / interventions tested

• Usual Care
• Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates

Conditions studied

• Liver Transplant; Complications — all drugs for Liver Transplant; Complications →
• Bleeding — all drugs for Bleeding →
• Hemostatic Disorder — all drugs for Hemostatic Disorder →

Sponsor

Hospital Israelita Albert Einstein

Who can join

18 and older, any sex, with Liver Transplant; Complications or Bleeding. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation.

METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Association between viscoelastic tests-guided therapy with synthetic factor concentrates and allogenic blood transfusion in liver transplantation: a before-after study.
   Zamper RPC, Amorim TC, Queiroz VNF, Lira JDO, et al · · 2018 · cited 20× · PMID 30579327 · DOI 10.1186/s12871-018-0664-8