NCT03753451

Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin

Completed NA Last updated 27 November 2018

What this trial tests

NA trial testing treatment of periodontal disease in Periodontal Diseases in 80 participants. Completed in 1 October 2018.

Timeline

1 October 2016

Primary endpoint
1 October 2018

1 October 2018

Quick facts

Lead sponsor	InCor Heart Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	80
Start date	1 October 2016
Primary completion	1 October 2018
Estimated completion	1 October 2018
Sites	2 locations across Brazil

Drugs / interventions tested

• treatment of periodontal disease

Conditions studied

• Periodontal Diseases — all drugs for Periodontal Diseases →

Sponsor

InCor Heart Institute

Who can join

45 and older, any sex, with Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The premise of the relationship between the atherosclerotic process of coronary artery disease and periodontal disease is the immunoinflammatory process, which causes a significant increase in serum concentration of mannose-binding lectin. This protein is part of the innate immunity and has the ability to bind to the mannose residues common to various pathogens. Animal studies also showed that increased serum concentration of sirtuin-1 was associated with reduced inflammation. Evidence indicates that sirtuin-1 plays an important role in vascular protection and is associated with aging. OBJECTIVES: This study examined the influence of non-surgical treatment of periodontal disease on the serum concentration of mannose-binding lectin and sirtuin-1 in patients with periodontal disease and coronary artery disease. METHODS: Seventy-eight patients, 38 women and 40 men, mean age 58 ± 8 years old, were divided into 4 groups: 20 healthy subjects (group 1), 18 patients with coronary artery disease and without periodontal disease (group 2), 20 patients with periodontal disease and without coronary artery disease (group 3) and 20 patients with coronary artery disease and periodontal disease (group 4). Peripheral blood samples were collected at the beginning and at the end of the treatment of periodontal disease.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease.
   Caribé PMV, Villar CC, Romito GA, Takada JY, et al · · 2020 · cited 9× · PMID 32435441 · DOI 10.1177/2040622320919621