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NCT03749044
ASA Patterns for Prevention of Preeclampsia in SLE Pregnancies
NA trial testing Patient Educational Tool in Pre-Eclampsia in 73 participants. Completed in 11 March 2024.
11 March 2024
Quick facts
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 73 |
| Start date | 28 May 2018 |
| Primary completion | 11 March 2024 |
| Estimated completion | 11 March 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Patient Educational Tool
Conditions studied
- Pre-Eclampsia — all drugs for Pre-Eclampsia →
- Pregnancy Complications — all drugs for Pregnancy Complications →
- Systemic Lupus — all drugs for Systemic Lupus →
Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Who can join
Adults 18 to 45, female only, with Pre-Eclampsia or Pregnancy Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Preeclampsia is a serious maternal condition affecting up to 5% of pregnancies from the general population and up to 30% of lupus pregnancies. Aspirin (acetylsalicylic acid- ASA) has been shown to reduce the risk of preeclampsia, by half, in women at high risk. Therefore, it is recommended that health professionals initiate aspirin early during pregnancy in women with lupus. Despite this recommendation, there are currently no studies of aspirin in women with lupus for this indication. This is a critical knowledge gap as aspirin could potentially have a large benefit in this high-risk population. The investigator will perform a RCT to evaluate the effect of a specifically designed patient educational tool on preeclampsia knowledge and ASA adherence in pregnant women with SLE. The research efforts will improve reproductive health of SLE women and the outcomes of offsprings.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
An educational tool to improve PREeclamPsia knowledge and Aspirin adheRence in lupus prEgnancies: the PREPARE trial.
Lee JE, Mendel A, Malhamé I, Barber MRW, et al · · 2025 · cited 2× · PMID 40578323 · DOI 10.1093/rheumatology/keaf334
Verify or expand the search:
- PubMed search for NCT03749044
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pre-Eclampsia
Currently open trials in the same condition.
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- NCT06122220 — Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia. · NA · recruiting
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Other McGill University Health Centre/Research Institute of the McGill University Health Centre trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03749044 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre
- Last refreshed: 13 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03749044.
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