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Repeat Quadratus Lumborum Block to Reduce Opioid Need in Patients After Pancreatic Surgery
Phase 2 trial testing Best Practice in Pancreatic Carcinoma in 136 participants. Completed in 31 July 2025.
| Lead sponsor | M.D. Anderson Cancer Center |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 136 |
| Start date | 28 February 2019 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
M.D. Anderson Cancer Center — full company profile →
18 and older, any sex, with Pancreatic Carcinoma. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Performed Chi-squared test to compare the proportion of patients who were opioid-free on the discharge date between the two arms
| Group | Value | 95% CI |
|---|---|---|
| Arm 1, Control Arm (Usual Care) | 19 | |
| Arm 2, Experimental Arm (2nd QL-Block) | 27 |
Time frame: 90 days from surgery. Reporting threshold: 1%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.
| Reaction | System | Arm 1, Control Arm (Usual … | Arm 2, Experimental Arm (2… |
|---|---|---|---|
| Pancreatic leak | Gastrointestinal disorders | — | — |
| GI Other | Gastrointestinal disorders | — | — |
| Chyle leak | Gastrointestinal disorders | — | — |
| Abscess | Infections and infestations | — | — |
| Sepsis | Infections and infestations | — | — |
| Delayed Gastric Emptying | Gastrointestinal disorders | — | — |
| BJ leak | Gastrointestinal disorders | — | — |
| Pneumonia | Respiratory, thoracic and mediastinal disorders | — | — |
| Pulmonary Other | Respiratory, thoracic and mediastinal disorders | — | — |
| Hemorrhage | Blood and lymphatic system disorders | — | — |
| Hematologic_ other | Blood and lymphatic system disorders | — | — |
| Sterile collection | Infections and infestations | — | — |
| Line infection | Infections and infestations | — | — |
| Infectious Other | Infections and infestations | — | — |
| Reaction | System | Arm 1, Control Arm (Usual … | Arm 2, Experimental Arm (2… |
|---|---|---|---|
| GI Other | Gastrointestinal disorders | — | — |
| Delayed Gastric Emptying | Gastrointestinal disorders | — | — |
| Pancreatic leak | Gastrointestinal disorders | — | — |
| Wound infection | Infections and infestations | — | — |
| Infectious Other | Infections and infestations | — | — |
| Post-op transfusion | Blood and lymphatic system disorders | — | — |
| Chyle leak | Gastrointestinal disorders | — | — |
| Renal other | Renal and urinary disorders | — | — |
| Cholangitis | Infections and infestations | — | — |
| Arrythmia | Cardiac disorders | — | — |
| Hematologic_ other | Blood and lymphatic system disorders | — | — |
| Urinary Tract Infection | Infections and infestations | — | — |
| Neurologic_Other | Nervous system disorders | — | — |
| Pneumonia | Respiratory, thoracic and mediastinal disorders | — | — |
| Edema | Respiratory, thoracic and mediastinal disorders | — | — |
| Hemorrhage | Blood and lymphatic system disorders | — | — |
| Acute Renal Failure | Renal and urinary disorders | — | — |
| Abscess | Infections and infestations | — | — |
| Colitis | Infections and infestations | — | — |
| Metabolic Other | Metabolism and nutrition disorders | — | — |
Most-reported serious reactions: Pancreatic leak, GI Other, Chyle leak, Abscess, Sepsis, Delayed Gastric Emptying, BJ leak, Pneumonia.
Data from ClinicalTrials.gov NCT03745794 adverse events section.
This phase II trial studies how an additional anesthetic nerve block, called a quadratus lumborum block, works to reduce the need for opioids in patients after pancreatic surgery. Giving an additional regional anesthetic after surgery may hasten the weaning process, reduce the need for opioid medications upon discharge, and reduce the risk of opioid dependence.
1 peer-reviewed publication reference this trial (live from Europe PMC):
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