NCT03743987 is a NA clinical trial of control group in Apical Periodontitis, sponsored by Recep Tayyip Erdogan University Training and Research Hospital.

Who is sponsoring NCT03743987?

NCT03743987 is sponsored by Recep Tayyip Erdogan University Training and Research Hospital.

What drugs are being tested in NCT03743987?

Interventions in NCT03743987: control group, MTA group, PRF group, MTA + PRF group.

What condition does NCT03743987 study?

NCT03743987 studies Apical Periodontitis, Wound Heal.

Is NCT03743987 still recruiting?

NCT03743987 is currently completed. Last updated 25 February 2019.

Last reviewed 2019-02-25 · How we verify

NCT03743987

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of MTA and PRF Application in Periapical Lesions

Completed NA Last updated 25 February 2019

What this trial tests

NA trial testing control group in Apical Periodontitis in 36 participants. Completed in 5 November 2018.

Timeline

20 December 2016

Primary endpoint
5 November 2018

5 November 2018

Quick facts

Lead sponsor	Recep Tayyip Erdogan University Training and Research Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	36
Start date	20 December 2016
Primary completion	5 November 2018
Estimated completion	5 November 2018
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

control group — full drug profile →
MTA group
PRF group
MTA + PRF group

Conditions studied

Apical Periodontitis — all drugs for Apical Periodontitis →
Wound Heal — all drugs for Wound Heal →

Sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Who can join

Adults 18 to 50, any sex, with Apical Periodontitis or Wound Heal. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form. Groups were divided in to 4; as control, MTA (mineral trioxide aggregate), PRF (platelet rich fibrin) and MTA+PRF groups. Apical resection was performed in all groups. No other interventions were made to the control group. Routine radiographs were taken in the 1st. 3th and 6th months. In the (approximately) 12th month of the procedures computerized tomography scans were taken. Primary healing of the periapical tissues were evaluated and the outcomes were measured. Patients have still been under control for the long term outcomes of the study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging.
Karan NB, Aricioğlu B. · · 2020 · cited 23× · PMID 31321573 · DOI 10.1007/s00784-019-03003-x

Verify or expand the search:

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Currently open trials in the same condition.

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Other Recep Tayyip Erdogan University Training and Research Hospital trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03743987 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Recep Tayyip Erdogan University Training and Research Hospital
Last refreshed: 25 February 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03743987.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing