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NCT03741725

Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Completed NA Results posted Last updated 7 July 2020
What this trial tests

NA trial testing Pay-it-forward in Gonorrhea Male in 301 participants. Completed in 2 September 2019.

Timeline
8 December 2018
Primary endpoint
2 September 2019
2 September 2019

Quick facts

Lead sponsorUniversity of North Carolina, Chapel Hill
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposescreening
Enrollment301
Start date8 December 2018
Primary completion2 September 2019
Estimated completion2 September 2019
Sites3 locations across China

Drugs / interventions tested

Conditions studied

Sponsor

University of North Carolina, Chapel Hill

Who can join

Adults 16 to 99, male only, with Gonorrhea Male or Chlamydia;M. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants Who Received the Dual Gonorrhea/Chlamydia Testing Primary · During enrollment visit, an approximate total of 1.5 hours

Dual gonorrhea/chlamydia test uptake as assessed by administrative records in each arm.

GroupValue95% CI
Pay-it-forward57
Pay-what-you-want46
Standard-of-care18
Number of Participants Tested Positive for Gonorrhea Secondary · During enrollment visit, an approximate total of 1.5 hours

The number of men who tested positive for gonorrhea through this study. Samples were collected either from urine or rectum.

GroupValue95% CI
Pay-it-forward1
Pay-what-you-want2
Standard of Care2
Number of Participants Tested Positive for Chlamydia Secondary · During enrollment visit, an approximate total of 1.5 hours

The is the number of men who tested positive for chlamydia through this study

GroupValue95% CI
Pay-it-forward8
Pay-what-you-want8
Standard of Care3
Cost Per Test Secondary · During enrollment visit, an approximate total of 1.5 hours

Cost per test, defined as the cost associated with respective interventions (development, start-up, implementation, intervention) per individual who reported testing for gonorrhea and chlamydia following the intervention; economic test and financial cost are reported separately.

Using economic cost
GroupValue95% CI
Pay-it-forward11.24± 1.64
Pay-what-you-want9.67± 1.46
Standard of Care6.12± 1.12
Using financial cost
GroupValue95% CI
Pay-it-forward6.52± 1.48
Pay-what-you-want6.56± 1.26
Standard of Care1.46± 0.62
Cost Per Diagnosis Secondary · During enrollment visit, an approximate total of 1.5 hours

Cost per diagnosis, defined as the cost associated with respective interventions (development, start-up, implementation, intervention) per individual who tested positive for gonorrhea and/or chlamydia following the intervention. Cost using economic cost and financial cost were respectively reported.

Using economic cost
GroupValue95% CI
Pay-it-forward11.24± 1.66
Pay-what-you-want9.67± 1.45
Standard of Care6.12± 1.13
Using financial cost
GroupValue95% CI
Pay-it-forward6.52± 1.47
Pay-what-you-want6.56± 1.29
Standard of Care1.46± 0.62
Number of Participants Reporting Community Engagement Activities Secondary · During enrollment visit, an approximate total of 1.5 hours

Number of participants who reported yes/no to specific questions on the awareness of and/or participation in MSM-related causes, organizations, or community events

Have you ever participated in online forums or dis
GroupValue95% CI
Pay-it-forward78
Pay-what-you-want64
Standard of Care61
Pay-it-forward17
Pay-what-you-want28
Standard of Care29
Are you aware of any ongoing MSM-related community
GroupValue95% CI
Pay-it-forward48
Pay-what-you-want30
Standard of Care37
Pay-it-forward45
Pay-what-you-want62
Standard of Care52
Have you ever encouraged someone to use MSM-relate
GroupValue95% CI
Pay-it-forward77
Pay-what-you-want72
Standard of Care70
Pay-it-forward16
Pay-what-you-want20
Standard of Care18
Have you ever attended MSM-related community event
GroupValue95% CI
Pay-it-forward31
Pay-what-you-want23
Standard of Care23
Pay-it-forward63
Pay-what-you-want69
Standard of Care69
Have you ever donated to MSM-related causes, event
GroupValue95% CI
Pay-it-forward41
Pay-what-you-want30
Standard of Care23
Pay-it-forward55
Pay-what-you-want62
Standard of Care71
Have you ever volunteered for MSM-related causes
GroupValue95% CI
Pay-it-forward19
Pay-what-you-want13
Standard of Care14
Pay-it-forward74
Pay-what-you-want78
Standard of Care76
Community Connectedness Scale Scores Secondary · During enrollment visit, an approximate total of 1.5 hours

Community connectedness scales include six statements and Likert scale response ranging from 1= Strongly disagree, 2= Agree, 3= Disagree, and 4= Strongly agree. For each scale item, the range spans across 1 to 4, with higher score indicating more agreement with the statement and potentially higher community connectedness.

You feel that you are a part of the MSM community.
GroupValue95% CI
Pay-it-forward3.32± 0.74
Pay-what-you-want3.05± 0.72
Standard of Care3.10± 0.63
Participating in MSM community is a positive thing
GroupValue95% CI
Pay-it-forward3.16± 0.77
Pay-what-you-want3.00± 0.73
Standard of Care3.00± 0.59
You are proud of the MSM community
GroupValue95% CI
Pay-it-forward2.75± 0.87
Pay-what-you-want2.71± 0.73
Standard of Care2.78± 0.78
Important for you to advocate for the community
GroupValue95% CI
Pay-it-forward3.24± 0.67
Pay-what-you-want3.23± 0.59
Standard of Care3.10± 0.70
If you all work together, problems will be solved
GroupValue95% CI
Pay-it-forward2.92± 0.83
Pay-what-you-want2.86± 0.69
Standard of Care2.88± 0.69
Any problems faced by the MSM are also yours
GroupValue95% CI
Pay-it-forward3.22± 0.60
Pay-what-you-want3.13± 0.62
Standard of Care3.02± 0.63
Social Cohesion Scale Scores Secondary · During enrollment visit, an approximate total of 1.5 hours

Social cohesion is a scale made of seven statements and Likert response to them ranging from 1= strongly disagree, 2 = disagree, 3 = agree, and 4= strongly agree. Those questions asked about the feelings of being able to depend on a larger MSM community (i.e., tongzhi circle, gay online networks or groups). For each item, the range spans across 1 to 4. For items 1 to 5, the higher score, the more agreement with the statement and potentially the higher social cohesion. Item 6 and 7 are reversely scored, meaning that the higher the score, the lower social cohesion potentially.

You can count on other MSM to lend money
GroupValue95% CI
Pay-it-forward2.52± 0.84
Pay-what-you-want2.57± 0.76
Standard of Care2.64± 0.72
You can count on other MSM to talk about problems
GroupValue95% CI
Pay-it-forward2.98± 0.69
Pay-what-you-want2.86± 0.75
Standard of Care2.98± 0.53
You can count on other MSM if you need a place
GroupValue95% CI
Pay-it-forward2.71± 0.81
Pay-what-you-want2.73± 0.76
Standard of Care2.73± 0.71
MSM you socialize with is an integrated group
GroupValue95% CI
Pay-it-forward2.63± 0.71
Pay-what-you-want2.68± 0.73
Standard of Care2.66± 0.68
You can trust the majority of the MSM you know.
GroupValue95% CI
Pay-it-forward2.74± 0.71
Pay-what-you-want2.59± 0.71
Standard of Care2.61± 0.66
MSM in your group only worry about themselves
GroupValue95% CI
Pay-it-forward2.48± 0.71
Pay-what-you-want2.54± 0.76
Standard of Care2.47± 0.67
MSM you socialize with are always arguing
GroupValue95% CI
Pay-it-forward2.31± 0.69
Pay-what-you-want2.18± 0.77
Standard of Care2.26± 0.62

Sponsor's own description

This is a randomized controlled trial which will evaluate dual gonorrhea/chlamydia test uptake and other outcomes in men who have sex with men (MSM) in three trial arms - 1) a pay-it-forward testing arm, 2) a pay-what-you-want testing arm, and 3) standard of care arm.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Pay-it-forward gonorrhoea and chlamydia testing among men who have sex with men in China: a randomised controlled trial.
    Yang F, Zhang TP, Tang W, Ong JJ, et al · · 2020 · cited 41× · PMID 32530426 · DOI 10.1016/s1473-3099(20)30172-9
  2. Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial.
    Zhang TP, Yang F, Tang W, Alexander M, et al · · 2019 · cited 11× · PMID 31426869 · DOI 10.1186/s40249-019-0581-1
  3. Development of a Psychometric Tool to Measure Community Solidarity Among Sexual Minorities: Evidence From a Pay-it-Forward Randomized Controlled Trial.
    Sung A, Zhang TP, Huang W, Tang W, et al · · 2022 · cited 8× · PMID 35675708 · DOI 10.1097/olq.0000000000001659
  4. Lack of sexual behavior disclosure may distort STI testing outcomes.
    Kumar N, Forastiere L, Zhang T, Yang F, et al · · 2020 · cited 7× · PMID 32366241 · DOI 10.1186/s12889-020-08768-5

Verify or expand the search:

Other recruiting trials for Gonorrhea Male

Currently open trials in the same condition.

Other University of North Carolina, Chapel Hill trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03741725.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing