NCT03736018 (BYPASS-CTCA) is a NA clinical trial of CTCA in Ischaemic Heart Disease, sponsored by Queen Mary University of London.

Who is sponsoring NCT03736018?

NCT03736018 is sponsored by Queen Mary University of London.

What drugs are being tested in NCT03736018?

Interventions in NCT03736018: CTCA.

What condition does NCT03736018 study?

NCT03736018 studies Ischaemic Heart Disease, Contrast-induced Nephropathy.

Is NCT03736018 still recruiting?

NCT03736018 is currently status unknown. Last updated 15 December 2022.

Last reviewed 2022-12-15 · How we verify

NCT03736018: BYPASS-CTCA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients

Status unknown NA Last updated 15 December 2022

What this trial tests

NA trial testing CTCA in Ischaemic Heart Disease in 688 participants. Status unknown.

Timeline

15 November 2018

Primary endpoint
30 August 2022

30 September 2023

Quick facts

Lead sponsor	Queen Mary University of London
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	688
Start date	15 November 2018
Primary completion	30 August 2022
Estimated completion	30 September 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

CTCA

Conditions studied

Ischaemic Heart Disease — all drugs for Ischaemic Heart Disease →
Contrast-induced Nephropathy — all drugs for Contrast-induced Nephropathy →

Sponsor

Queen Mary University of London

Who can join

18 and older, any sex, with Ischaemic Heart Disease or Contrast-induced Nephropathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A large number of patients with symptomatic ischaemic heart disease undergo coronary artery bypass grafting (CABG) to alleviate their symptoms and improve prognosis. Given the progressive nature of coronary disease, bypass grafts can narrow or block over time, leading to chest pain and the need for further invasive coronary angiography. Invasive coronary procedures in patients with bypass grafts can be more complicated due to the variation in bypass graft ostia. This can lead to longer procedure times, with higher doses of contrast and radiation and more discomfort for the patient. The aim of this study is to see if the use of computed tomography cardiac angiography (CTCA) in patients with previous bypass grafts prior to invasive coronary angiography will help make their procedure safer and quicker.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass Surgery: The BYPASS-CTCA Trial.
Jones DA, Beirne AM, Kelham M, Rathod KS, et al · · 2023 · cited 36× · PMID 37772419 · DOI 10.1161/circulationaha.123.064465
The BYPASS-CTCA Study: the value of Computed Tomography Cardiac Angiography (CTCA) in improving patient-related outcomes in patients with previous bypass operation undergoing invasive coronary angiography: Study Protocol of a Randomised Controlled Trial.
Beirne AM, Rathod KS, Castle E, Andiapen M, et al · · 2021 · cited 8× · PMID 34733947 · DOI 10.21037/atm-21-1455
CTCA Prior to Invasive Coronary Angiography in Patients With Previous Bypass Surgery: Patient-Related Outcomes, Imaging Resource Utilization, and Cardiac Events at 3 Years From the BYPASS-CTCA Trial.
Kelham M, Beirne AM, Rathod KS, Andiapen M, et al · · 2024 · cited 2× · PMID 39584261 · DOI 10.1161/circinterventions.124.014142
The effect of CTCA guided selective invasive graft assessment on coronary angiographic parameters and outcomes: Insights from the BYPASS-CTCA trial.
Kelham M, Beirne AM, Rathod KS, Andiapen M, et al · · 2024 · cited 2× · PMID 38462389 · DOI 10.1016/j.jcct.2024.03.004

Verify or expand the search:

Other trials of CTCA

Trials testing the same drug.

NCT07165678 — CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2) · NA · not yet recruiting
NCT06765785 — Cardiovascular Screening in Asymptomatic South Asians · NA · not yet recruiting
NCT06681584 — Comparison of the Diagnostic Performance and Costs of FFRB Vs. Standard Care in Suspected Coronary Artery Disease. · active not recruiting
NCT07212751 — Coronary CT Angiogram - Prognostic Value of Adverse Plaque Features in Guiding Treatment (CT-PLAQUE) · active not recruiting
NCT07022626 — Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surg · NA · completed

Other recruiting trials for Ischaemic Heart Disease

Currently open trials in the same condition.

NCT07035171 — CABGpreHAB - a Feasibility Study Protocol · NA · recruiting
NCT04014140 — iFR Guided Coronary Artery Bypass Grafting Surgery · recruiting
NCT04674449 — iCorMicA - Stratified Medicine in Angina · NA · recruiting
NCT04193475 — Machine Learning in Quantitative Stress Echocardiography · recruiting
NCT03603210 — Outcomes of Drug Coated Balloon Angioplasty, A UK Real Life Experience From 2009 to 2015 · active not recruiting

Other Queen Mary University of London trials

Trials by the same sponsor.

NCT07246005 — LVT DURATION: Pilot Study of Anticoagulation Duration for Left Ventricular Thrombus · Phase 2 · not yet recruiting
NCT07165678 — CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2) · NA · not yet recruiting
NCT06937372 — Delivery and Implementation of a Randomised Crossover Trial on Thrombosis · NA · not yet recruiting
NCT06600438 — Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial · NA · not yet recruiting
NCT06987045 — Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03736018 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Queen Mary University of London
Last refreshed: 15 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03736018.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing