NCT03734393

HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients

Active, enrolled NA Last updated 9 March 2026

What this trial tests

NA trial testing HIVD+/R+ in Hiv in 80 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

4 January 2019

Primary endpoint
12 June 2025

30 April 2026

Quick facts

Lead sponsor	Johns Hopkins University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	80
Start date	4 January 2019
Primary completion	12 June 2025
Estimated completion	30 April 2026
Sites	26 locations across United States

Drugs / interventions tested

• HIVD+/R+

Conditions studied

• Hiv — all drugs for Hiv →

Sponsor

Johns Hopkins University

Who can join

18 and older, any sex, with Hiv. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.
   Durand CM, Florman S, Motter JD, Brown D, et al · · 2022 · cited 60× · PMID 34741800 · DOI 10.1111/ajt.16886
2. National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States.
   Werbel WA, Brown DM, Kusemiju OT, Doby BL, et al · · 2022 · cited 19× · PMID 34453519 · DOI 10.1093/cid/ciab743
3. Incidence and Outcomes of COVID-19 in Kidney and Liver Transplant Recipients With HIV: Report From the National HOPE in Action Consortium.
   Mehta SA, Mehta SA, Rana MM, Motter JD, et al · · 2021 · cited 19× · PMID 33165238 · DOI 10.1097/tp.0000000000003527
4. Barriers experienced by organ procurement organizations in implementing the HOPE act and HIV-positive organ donation.
   Predmore Z, Doby B, Bozzi DG, Durand C, et al · · 2022 · cited 18× · PMID 34180726 · DOI 10.1080/09540121.2021.1945999
5. Science Over Stigma: Lessons and Future Direction of HIV-to-HIV Transplantation.
   Klitenic SB, Levan ML, Van Pilsum Rasmussen SE, Durand CM. · · 2021 · cited 11× · PMID 34812403 · DOI 10.1007/s40472-021-00345-y
6. Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results.
   Durand CM, Werbel W, Doby B, Brown D, et al · · 2020 · cited 10× · PMID 31675457 · DOI 10.1111/ajt.15681
7. Organ transplantation in persons with HIV.
   Kumar RN, Stosor V. · · 2020 · cited 8× · PMID 32167973 · DOI 10.1097/qad.0000000000002518
8. HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV.
   Benner SE, Zhu X, Hussain S, Florman S, et al · · 2023 · cited 5× · PMID 37379584 · DOI 10.1093/infdis/jiad241