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NCT03731104: CIRCU-REAPED
Cerebral Circulation in Critically Ill Children
trial testing Near InfraRed Spectroscopy assessment in Arterial Hypotension in 27 participants. Completed in 2 July 2021.
2 July 2021
Quick facts
| Lead sponsor | Assistance Publique - Hôpitaux de Paris |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 27 |
| Start date | 13 December 2018 |
| Primary completion | 2 July 2021 |
| Estimated completion | 2 July 2021 |
| Sites | 3 locations across France |
Drugs / interventions tested
- Near InfraRed Spectroscopy assessment
- Transcranial Doppler Ultrasound assessment
- Cardiac output assessment
Conditions studied
- Arterial Hypotension — all drugs for Arterial Hypotension →
- Shock — all drugs for Shock →
- Cerebral Lesion — all drugs for Cerebral Lesion →
Sponsor
Assistance Publique - Hôpitaux de Paris — full company profile →
Who can join
Adults 0 to 18, any sex, with Arterial Hypotension or Shock. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The principal purpose of this study is to describe the changes in cerebral circulation (assessed by transcranial ultrasound) and oxygenation (assessed by Near InfraRed spectroscopy, NIRS) during resuscitation for hemodynamic failure (arterial hypotension or shock) in critically ill children treated with vasoactive or inotropic drugs. The secondary objectives are : i) to evaluate the association between an alteration of cerebral circulation and/or oxygenation and an alteration in macro-circulatory parameters (Mean Arterial Blood Pressure and cardiac output) or a bad outcome, ii) to study if cerebral autoregulation is impaired
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Low Dosing Norepinephrine Effects on Cerebral Oxygenation and Perfusion During Pediatric Shock.
Vedrenne-Cloquet M, Chareyre J, Léger PL, Genuini M, et al · · 2022 · cited 2× · PMID 35874564 · DOI 10.3389/fped.2022.898444
Verify or expand the search:
- PubMed search for NCT03731104
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Arterial Hypotension
Currently open trials in the same condition.
- NCT06639737 — Preoperative Blood Volume Optimization Using Transthoracic Echocardiography · NA · recruiting
Other Assistance Publique - Hôpitaux de Paris trials
Trials by the same sponsor.
- NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
- NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
- NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
- NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
- NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03731104 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
- Last refreshed: 12 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03731104.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing