NCT03729011 (DELICATE) is a Phase 4 clinical trial of Volatile agent in Delirium, sponsored by Meshalkin Research Institute of Pathology of Circulation.

Who is sponsoring NCT03729011?

NCT03729011 is sponsored by Meshalkin Research Institute of Pathology of Circulation.

What drugs are being tested in NCT03729011?

Interventions in NCT03729011: Volatile agent, Propofol.

Is NCT03729011 still recruiting?

NCT03729011 is currently completed. Last updated 15 May 2025.

Last reviewed 2025-05-15 · How we verify

NCT03729011: DELICATE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Delirium Reduction by Volatile Anesthesia in Cardiac Surgery

Completed Phase 4 Last updated 15 May 2025

What this trial tests

Phase 4 trial testing Volatile agent in Delirium in 405 participants. Completed in 11 January 2024.

Timeline

9 January 2019

Primary endpoint
11 January 2024

11 January 2024

Quick facts

Lead sponsor	Meshalkin Research Institute of Pathology of Circulation
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	405
Start date	9 January 2019
Primary completion	11 January 2024
Estimated completion	11 January 2024
Sites	5 locations across Russia

Drugs / interventions tested

Volatile agent — full drug profile →
Propofol (Propofol) — full drug profile →

Conditions studied

Delirium — all drugs for Delirium →

Sponsor

Meshalkin Research Institute of Pathology of Circulation

Who can join

65 and older, any sex, with Delirium. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Parallel group, prospective, randomized, controlled, single-blinded trial. The aim of our study is to test the hypothesis that volatile anesthesia would reduce the incidence of early postoperative delirium in patients undergoing cardiac surgery with CPB as compared to TIVA.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Volatile versus Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery: Analysis of 1586 MYRIAD Trial Patients Managed with the Same Perioperative Protocol.
Lomivorotov V, Ruzankin PS, Lembo R, Tarasenko AS, et al · · 2022 · cited 1× · PMID 39076624 · DOI 10.31083/j.rcm2308265

Verify or expand the search:

Other recruiting trials for Delirium

Currently open trials in the same condition.

NCT07348471 — Fecal Microbiota Transplantation for the Treatment of ICU Delirium · NA · recruiting
NCT06969287 — Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery · Phase 3 · recruiting
NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
NCT07136207 — Development and Validation of Delirium Recognition Using Computer Vision in Neuro-critical Patients · recruiting

Other Meshalkin Research Institute of Pathology of Circulation trials

Trials by the same sponsor.

NCT07372196 — Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy · NA · recruiting
NCT06443931 — Cryoablation of Intercostal Nerves for Pain Management in Early Postoperative Period in Patients With Minimally Invasive · NA · completed
NCT06069115 — Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort · recruiting
NCT05856461 — Pulmonary Artery Denervation in Patients With Atrial Fibrillation and Group 2 of Pulmonary Hypertension · NA · unknown
NCT05643664 — The Role of Artificial Intelligence in the Treatment of Abdominal Aortic Aneurysms · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03729011 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Meshalkin Research Institute of Pathology of Circulation
Last refreshed: 15 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03729011.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing