NCT03728218 (VOTE) is a NA clinical trial of Contact lenses (Orthokeratology) in Astigmatism, sponsored by University of Houston.

Who is sponsoring NCT03728218?

NCT03728218 is sponsored by University of Houston.

What drugs are being tested in NCT03728218?

Interventions in NCT03728218: Contact lenses (Orthokeratology), Contact lenses (Soft Multifocal).

What condition does NCT03728218 study?

NCT03728218 studies Astigmatism, Myopia.

Is NCT03728218 still recruiting?

NCT03728218 is currently completed. Last updated 14 July 2020.

Last reviewed 2020-07-14 · How we verify

NCT03728218: VOTE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Visual Outcomes for Toric Efficacy Study

Completed NA Last updated 14 July 2020

What this trial tests

NA trial testing Contact lenses (Orthokeratology) in Astigmatism in 34 participants. Completed in 19 March 2020.

Timeline

12 October 2018

Primary endpoint
19 March 2020

19 March 2020

Quick facts

Lead sponsor	University of Houston
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	other
Enrollment	34
Start date	12 October 2018
Primary completion	19 March 2020
Estimated completion	19 March 2020
Sites	1 location across United States

Drugs / interventions tested

Contact lenses (Orthokeratology)
Contact lenses (Soft Multifocal)

Conditions studied

Astigmatism — all drugs for Astigmatism →
Myopia — all drugs for Myopia →

Sponsor

University of Houston

Who can join

Adults 18 to 39, any sex, with Astigmatism or Myopia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a crossover study of two types of contact lenses (toric orthokeratology and soft multifocals). Primary aims are to quantify correction of astigmatism, subjective and objective visual performance, aberrometry, peripheral refraction and bacterial bioburden between toric orthokeratology and soft toric multifocal contact lenses.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Corneal Elevation, Power, and Astigmatism to Assess Toric Orthokeratology Lenses in Moderate-to-High Astigmats.
Tomiyama ES, Logan AK, Richdale K. · · 2021 · cited 17× · PMID 32568927 · DOI 10.1097/icl.0000000000000721
Peripheral Refraction With Toric Orthokeratology and Soft Toric Multifocal Contact Lenses in Myopic Astigmatic Eyes.
Tomiyama ES, Berntsen DA, Richdale K. · · 2022 · cited 15× · PMID 35819285 · DOI 10.1167/iovs.63.8.10
Greater higher order aberrations induced by toric orthokeratology versus soft toric multifocal contact lens wear.
Tomiyama ES, Hu C, Marsack JD, Richdale K. · · 2021 · cited 8× · PMID 34076904 · DOI 10.1111/opo.12839
Clinical Outcomes of a Randomized Trial with Contact Lenses for Astigmatic Myopia Management.
Tomiyama ES, Richdale K. · · 2023 · cited 3× · PMID 36705710 · DOI 10.1097/opx.0000000000001969

Verify or expand the search:

Other recruiting trials for Astigmatism

Currently open trials in the same condition.

NCT07303920 — Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear Day · NA · recruiting
NCT07284966 — Comfort and Vision With TOTAL30 Multifocal Lenses · recruiting
NCT07078799 — Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery · NA · recruiting
NCT07084844 — Patient Reported Outcomes With WaveLight Plus LASIK · recruiting
NCT07140653 — Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery · Phase 4 · recruiting

Other University of Houston trials

Trials by the same sponsor.

NCT07024992 — Enhancing Smoking Cessation for African American People Everywhere · Phase 2 · not yet recruiting
NCT07025772 — Shaping Habitual Impulses For a Tobacco-free Style · NA · recruiting
NCT07007195 — Smart Olfaction App to Reduce Relapse · EARLY_PHASE1 · not yet recruiting
NCT06918821 — Reducing Obesity Through Play Among Toddlers: Tiny Steps to Health (TSHS) Study · NA · recruiting
NCT07227220 — Summer Youth Employment Programs for Health Promotion · EARLY_PHASE1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03728218 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Houston
Last refreshed: 14 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03728218.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing