NCT03721822 is a Phase 1 clinical trial of [18F]NOS in Smoking, Cigarette, sponsored by University of Pennsylvania.

Who is sponsoring NCT03721822?

NCT03721822 is sponsored by University of Pennsylvania.

What drugs are being tested in NCT03721822?

Interventions in NCT03721822: [18F]NOS.

What condition does NCT03721822 study?

NCT03721822 studies Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer.

Is NCT03721822 still recruiting?

NCT03721822 is currently recruiting now. Last updated 3 October 2025.

Last reviewed 2025-10-03 · How we verify

NCT03721822

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

Recruiting now Phase 1 Last updated 3 October 2025

What this trial tests

Phase 1 trial testing [18F]NOS in Smoking, Cigarette in 100 participants. Currently enrolling.

Timeline

23 October 2018

Primary endpoint
23 October 2026

23 October 2026

Quick facts

Lead sponsor	University of Pennsylvania
Phase	Phase 1
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	100
Start date	23 October 2018
Primary completion	23 October 2026
Estimated completion	23 October 2026
Sites	1 location across United States

Drugs / interventions tested

[18F]NOS

Conditions studied

Smoking, Cigarette — all drugs for Smoking, Cigarette →
Smoking E-cigarette — all drugs for Smoking E-cigarette →
Healthy Volunteer — all drugs for Healthy Volunteer →

Sponsor

University of Pennsylvania

Who can join

Adults 18 to 45, any sex, with Smoking, Cigarette or Smoking E-cigarette. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imaging drug that is labeled with a radioactive tag and injected into the body.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of [18F]NOS

Trials testing the same drug.

NCT05885594 — Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study · EARLY_PHASE1 · active not recruiting
NCT04401917 — Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls · EARLY_PHASE1 · active not recruiting
NCT04274998 — Neuroinflammation Imaging in AD · EARLY_PHASE1 · active not recruiting

Other recruiting trials for Smoking, Cigarette

Currently open trials in the same condition.

NCT07129590 — Trauma-Informed Care for Smoking Cessation for Pregnancy · NA · recruiting
NCT06945120 — ACT Lung Health Intervention: Phase Two · NA · recruiting
NCT06693700 — A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home · NA · recruiting
NCT06535867 — The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorde · recruiting
NCT05660525 — Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia · NA · recruiting

Other University of Pennsylvania trials

Trials by the same sponsor.

NCT06081153 — Mechanistic Clinical Trial of PCSK9 Inhibition for AAA · EARLY_PHASE1 · not yet recruiting
NCT07415772 — Effect of cTBS on Startle and TMS-evoked BOLD · NA · not yet recruiting
NCT07489430 — DaxibotulinumtoxinA for Blepharospasm · Phase 2 · not yet recruiting
NCT07463131 — Negative Income Tax Trial · NA · not yet recruiting
NCT06645769 — Na-Phenylbutyrate VAscular Trial · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03721822 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
Last refreshed: 3 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03721822.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing