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Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imaging drug that is labeled with a radioactive tag and injected into the body. This study will see how the tracer is taken up in the brain using an imaging scan called Positron Emission Tomography / Computed Tomography (PET/CT). Participants will undergo approximately 60 minutes of dynamic scanning of the brain starting at approximately the time of injection of \[18F\]NOS. Participants are required to have a brain MRI performed within 1 year prior to study enrollment, or if the subject has not had a brain MRI that is deemed acceptable for use for this study they will be asked to undergo a research brain MRI after they have consented for this study.
Details
| Lead sponsor | University of Pennsylvania |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 26 |
| Start date | Mon Dec 07 2020 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- HIV Infections
- Opioid Use
Interventions
- [18F]NOS
Countries
United States