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NCT03719248
Thoracic Epidural Reduces Risks of Increased Left Ventricular Mass Index During Coronary Artery Bypass Graft Surgery
NA trial testing thoracic epidural in Ischemia Coronary Artery Origin in 80 participants. Completed in 1 January 2018.
1 January 2018
Quick facts
| Lead sponsor | Ahmed Said Elgebaly,MD |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 80 |
| Start date | 1 January 2017 |
| Primary completion | 1 January 2018 |
| Estimated completion | 1 January 2018 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- thoracic epidural — full drug profile →
Conditions studied
- Ischemia Coronary Artery Origin — all drugs for Ischemia Coronary Artery Origin →
Sponsor
Ahmed Said Elgebaly,MD
Who can join
Adults 65 to 75, any sex, with Ischemia Coronary Artery Origin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Increased left ventricular mass index (LVMI) results from aortic valve lesions as an adaptive mechanism to help limit systolic wall stress and preserve ejection fraction (EF). This study Aim to investigate the effects of sympathetic blockade by HTEA on systolic and diastolic LV function in patients undergoing aortic valve replacement (AVR) alone or in addition to coronary artery bypass graft (CABG). It Designs as A prospective randomized controlled comparative study in which eighty patients received either general anesthesia ( control group n=40) or with high thoracic epidural analgesia(HTEA group n=40). Each group subdivided to normal (LVM) (n=20)or increased(LVM) group(n=20), all submitted to (AVR) alone or in addition to (CABG).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass.
Guay J, Kopp S. · · 2019 · cited 26× · PMID 30821845 · DOI 10.1002/14651858.cd006715.pub3 -
High thoracic epidural decreases perioperative myocardial ischemia and improves left ventricle function in aortic valve replacement alone or in addition to cabg surgery even with increased left ventricle mass index.
Elgebaly AS, Fathy SM, Elbarbary Y, Sallam AA. · · 2020 · cited 5× · PMID 32275028 · DOI 10.4103/aca.aca_203_18
Verify or expand the search:
- PubMed search for NCT03719248
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of thoracic epidural
Trials testing the same drug.
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- NCT03933592 — Ultrasound Guided Serratus Plane Block Versus Thoracic Epidural for Post Thoracotomy Pain · NA · completed
- NCT04518579 — Epidural-inhalational Versus Epidural-intravenous Anaesthesia on Anti-tumor Immunity in Patients With Cancer Colon · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03719248 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ahmed Said Elgebaly,MD
- Last refreshed: 25 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03719248.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing