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NCT03717831
Muscle Dysfunction in Critical Illness
trial testing Observational study of standard of care in Critical Illness in 66 participants. Completed in 15 July 2019.
1 July 2019
Quick facts
| Lead sponsor | University of Kentucky |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 66 |
| Start date | 17 October 2018 |
| Primary completion | 1 July 2019 |
| Estimated completion | 15 July 2019 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Observational study of standard of care
Conditions studied
- Critical Illness — all drugs for Critical Illness →
- Intensive Care (ICU) Myopathy — all drugs for Intensive Care (ICU) Myopathy →
- PICS — all drugs for PICS →
- Muscle Weakness — all drugs for Muscle Weakness →
Sponsor
University of Kentucky
Who can join
18 and older, any sex, with Critical Illness or Intensive Care (ICU) Myopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients surviving critical illness suffered significant skeletal muscle dysfunction and weakness that impacts their functionality and independence. The primary purpose of this project is to develop a classification system based on the health and function of the muscle at very early time points during critical illness. The investigators will determine if muscle ultrasound can predict functional recovery at six-months post hospital discharge. Researchers will assess muscle health and function from starting day one of admission to ICU and continue until six months of recovery. In addition to muscle ultrasound, the investigators will assess muscle strength and power, and perform muscle tissue analysis on a subset of individuals. These findings will be correlated to physical function and independence at six-month follow-up.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19.
Mayer KP, Ismaeel A, Kalema AG, Montgomery-Yates AA, et al · · 2024 · cited 11× · PMID 39412208 · DOI 10.1097/cce.0000000000001164
Verify or expand the search:
- PubMed search for NCT03717831
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03717831 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Kentucky
- Last refreshed: 31 January 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03717831.
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