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NCT03716934: craft
CRyoAblation vs AntiaRrhythmic Drugs for Persistent Atrial Fibrillation Trial
Phase 4 trial testing Arctic Front Advance® balloon catheter in Atrial Fibrillation in 196 participants. Completed in 18 April 2022.
18 April 2022
Quick facts
| Lead sponsor | Hospital San Carlos, Madrid |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 196 |
| Start date | 27 June 2018 |
| Primary completion | 18 April 2022 |
| Estimated completion | 18 April 2022 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Arctic Front Advance® balloon catheter
- Antiarrhythmic drug — full drug profile →
- Confirm RX heart monitor® (Abbott)
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
Sponsor
Hospital San Carlos, Madrid
Who can join
Adults 18 to 75, any sex, with Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective, randomized, multicenter study comparing the relative efficacy and safety of cryoablation of PVs using the Arctic Front Advance® balloon catheter with antiarrhythmic therapy in patients with persistent AF.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03716934
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrial Fibrillation
Currently open trials in the same condition.
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- NCT07271238 — Feasibility Study on the VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures · NA · recruiting
- NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
- NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
- NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
Other Hospital San Carlos, Madrid trials
Trials by the same sponsor.
- NCT06310941 — Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection · NA · not yet recruiting
- NCT07002658 — Clinical Impact of Surgical Wound Morbidity According to the Type of Saphenous Vein Harvesting Technique (Endoscopic vs. · NA · not yet recruiting
- NCT06113939 — Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning · NA · not yet recruiting
- NCT06156059 — Oral Bedtime Melatonin in Critically Ill Patients · Phase 4 · unknown
- NCT07390175 — Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03716934 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital San Carlos, Madrid
- Last refreshed: 15 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03716934.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing