Who is sponsoring NCT03715283?

NCT03715283 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT03715283?

Interventions in NCT03715283: Home Ankle Strengthing Program, Standard of Care.

What condition does NCT03715283 study?

NCT03715283 studies Charcot-Marie-Tooth Disease.

Is NCT03715283 still recruiting?

NCT03715283 is currently completed. Last updated 20 December 2019.

Last reviewed 2019-12-20 · How we verify

NCT03715283

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Change in MUNIX in Patients With CMT1A Undergoing a Home Ankle Strengthening Program Versus Standard of Care

Completed NA Last updated 20 December 2019

What this trial tests

NA trial testing Home Ankle Strengthing Program in Charcot-Marie-Tooth Disease in 19 participants. Completed in 1 September 2019.

Timeline

15 January 2019

Primary endpoint
1 September 2019

1 September 2019

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	diagnostic
Enrollment	19
Start date	15 January 2019
Primary completion	1 September 2019
Estimated completion	1 September 2019
Sites	1 location across United States

Drugs / interventions tested

Home Ankle Strengthing Program
Standard of Care

Conditions studied

Charcot-Marie-Tooth Disease — all drugs for Charcot-Marie-Tooth Disease →

Sponsor

Vanderbilt University Medical Center

Who can join

18 and older, any sex, with Charcot-Marie-Tooth Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Here the investigators aim to show that a focused lower extremity resistance strength training program in patients with Charcot-Marie-Tooth disease (CMT) results in increased motor strength of ankle plantar- and dorsi-flexion. The investigators will use motor unit index MUNIX and hand held dynamometry to correlate strength changes. The investigators believe that increased strength will correlate with an increased motor unit number and as such will prove that axonal renervation or improved recruitment is possible with a focused exercises in patients with CMT. Additionally, the investigators will show that that MUNIX declines over a 12-week period in patients with CMT whom continue standard of care. This will identify MUNIX as a responsive marker for disease progression in addition to detecting functional improvement, which will be valuable for future clinical trials.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Novel Therapeutic Approaches in Inherited Neuropathies: A Systematic Review.
Hustinx M, Shorrocks AM, Servais L. · · 2023 · cited 4× · PMID 37376074 · DOI 10.3390/pharmaceutics15061626

Verify or expand the search:

Other recruiting trials for Charcot-Marie-Tooth Disease

Currently open trials in the same condition.

NCT06203093 — Charcot-Marie-Tooth Disease (CMT) Biological Sample Collection for IPSC Generation and Biobanking · recruiting
NCT04762758 — Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients · Phase 3 · active not recruiting
NCT04010188 — A Registered Cohort Study on Charcot-Marie-Tooth Disease · recruiting
NCT05902351 — Natural History Study for Charcot Marie Tooth Disease · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

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NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03715283 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 20 December 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03715283.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing