NCT03704727 is a NA clinical trial of Probiotic in Intestinal Permeability, sponsored by University of Copenhagen.

Who is sponsoring NCT03704727?

NCT03704727 is sponsored by University of Copenhagen.

What drugs are being tested in NCT03704727?

Interventions in NCT03704727: Probiotic.

What condition does NCT03704727 study?

NCT03704727 studies Intestinal Permeability, Gastrointestinal Irritation, Mucositis.

Is NCT03704727 still recruiting?

NCT03704727 is currently completed. Last updated 18 April 2019.

Last reviewed 2019-04-18 · How we verify

NCT03704727

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy

Completed NA Last updated 18 April 2019

What this trial tests

NA trial testing Probiotic in Intestinal Permeability in 5 participants. Completed in 1 February 2019.

Timeline

1 July 2018

Primary endpoint
1 February 2019

1 February 2019

Quick facts

Lead sponsor	University of Copenhagen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	5
Start date	1 July 2018
Primary completion	1 February 2019
Estimated completion	1 February 2019
Sites	1 location across Denmark

Drugs / interventions tested

Probiotic

Conditions studied

Intestinal Permeability — all drugs for Intestinal Permeability →
Gastrointestinal Irritation — all drugs for Gastrointestinal Irritation →
Mucositis — all drugs for Mucositis →

Sponsor

University of Copenhagen

Who can join

18 and older, any sex, with Intestinal Permeability or Gastrointestinal Irritation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability. Furthermore, we hypothesize that the use of probiotics may reduce the occurrence of gastrointestinal side effects such as diarrhea, abdominal pains, bacterial translocation and infections following chemotherapy.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Bringing microbiome-drug interaction research into the clinic.
Guthrie L, Kelly L. · · 2019 · cited 48× · PMID 31151933 · DOI 10.1016/j.ebiom.2019.05.009
Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.
Zhu R, Lang T, Yan W, Zhu X, et al · · 2021 · cited 42× · PMID 34026439 · DOI 10.1002/advs.202003542
Gut microbiome homeostasis and the future of probiotics in cancer immunotherapy.
Singh A, Alexander SG, Martin S. · · 2023 · cited 35× · PMID 37261348 · DOI 10.3389/fimmu.2023.1114499

Verify or expand the search:

Other trials of Probiotic

Trials testing the same drug.

NCT07529457 — Akk09 in Adults With Constipation · NA · not yet recruiting
NCT07507955 — Probiotics for Constipation Relief in Adults · NA · not yet recruiting
NCT07462481 — Probiotic Improve Constipation · NA · recruiting
NCT07511855 — Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term T · Phase 2 · not yet recruiting
NCT07474064 — Probiotics Combined With Targeted Therapy Plus Immunotherapy in Bladder-Preserving Setting for Patients With MIBC · Phase 2 · not yet recruiting

Other recruiting trials for Intestinal Permeability

Currently open trials in the same condition.

NCT04083950 — Induction of Gut Permeability by an Oral Vaccine · EARLY_PHASE1 · active not recruiting

Other University of Copenhagen trials

Trials by the same sponsor.

NCT07461324 — Surgeons' Prediction of Dental Surgery Complications and the Influence of Patient Characteristics: Development of an AI · not yet recruiting
NCT07389421 — School Meals in Denmark · NA · not yet recruiting
NCT07450690 — Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy · NA · recruiting
NCT07302880 — The Acute Interference of Biotin in Blood Analysis · NA · not yet recruiting
NCT07312981 — The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03704727 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Copenhagen
Last refreshed: 18 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03704727.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing