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NCT07450690: MM-EX
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy
NA trial testing Unilateral high-intensity interval training (HIIT) in Mitochondrial Diseases in 22 participants. Currently enrolling.
30 October 2026
Quick facts
| Lead sponsor | University of Copenhagen |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 22 |
| Start date | 9 January 2026 |
| Primary completion | 30 October 2026 |
| Estimated completion | 30 October 2030 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Unilateral high-intensity interval training (HIIT)
Conditions studied
- Mitochondrial Diseases — all drugs for Mitochondrial Diseases →
- Mitochondrial Myopathy — all drugs for Mitochondrial Myopathy →
Sponsor
University of Copenhagen
Who can join
18 and older, any sex, with Mitochondrial Diseases or Mitochondrial Myopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults. The main questions it aims to answer are: * How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy? * How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy? Researchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups. The participants will: * Complete a 3-4-week supervised exercise training program using one leg. * Undergo muscle biopsies from both the trained and untrained leg. * Complete basic muscle strength and physical function tests.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07450690
- Europe PMC full search
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07450690 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Copenhagen
- Last refreshed: 5 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07450690.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing