Who is sponsoring NCT03695120?

NCT03695120 is sponsored by University of Florida.

What drugs are being tested in NCT03695120?

Interventions in NCT03695120: Change of treatment plan.

What condition does NCT03695120 study?

NCT03695120 studies Acute Decompensated Heart Failure.

Is NCT03695120 still recruiting?

NCT03695120 is currently completed. Last updated 22 April 2021.

Last reviewed 2021-04-22 · How we verify

NCT03695120: ROAD-HF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

RAAS Optimization for Acute CHF Patients

Completed NA Last updated 22 April 2021

What this trial tests

NA trial testing Change of treatment plan in Acute Decompensated Heart Failure in 1 participant. Completed in 12 April 2021.

Timeline

8 February 2019

Primary endpoint
12 April 2021

12 April 2021

Quick facts

Lead sponsor	University of Florida
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	1
Start date	8 February 2019
Primary completion	12 April 2021
Estimated completion	12 April 2021
Sites	1 location across United States

Drugs / interventions tested

Change of treatment plan

Conditions studied

Acute Decompensated Heart Failure — all drugs for Acute Decompensated Heart Failure →

Sponsor

University of Florida

Who can join

Adults 18 to 75, any sex, with Acute Decompensated Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Holding ACEI/ARBs during initial 72 hours of admission with acute decompensated heart failure may help preserve renal function with a lesser decline in GFR. This treatment modification will also allow the option of aggressive diuresis in volume overloaded CHF patients which should result in a lesser decline of AKI, length of stay, readmission rates, and cost associated with CHF treatment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Renin-Angiotensin-Aldosterone System Optimization for Acute Decompensated Heart Failure Patients (ROAD-HF): Rationale and Design.
Dass B, Dimza M, Singhania G, Schwartz C, et al · · 2020 · cited 1× · PMID 31797310 · DOI 10.1007/s40256-019-00389-7

Verify or expand the search:

Other recruiting trials for Acute Decompensated Heart Failure

Currently open trials in the same condition.

NCT07372040 — Add-on Diuretics in Acute Decompensated Heart Failure · Phase 2 · recruiting
NCT07199088 — Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Ac · NA · recruiting
NCT03951467 — Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations · NA · recruiting
NCT06556810 — IC14 for Treatment of Acute Decompensated Heart Failure · Phase 1, PHASE2 · active not recruiting
NCT06714409 — Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure · NA · recruiting

Other University of Florida trials

Trials by the same sponsor.

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NCT07492316 — RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · Phase 1 · not yet recruiting
NCT06670794 — Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Dri · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03695120 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Florida
Last refreshed: 22 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03695120.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing