NCT03689634: MFS

Move For Surgery - A Novel Preconditioning Program

Completed Phase 3 Last updated 3 July 2023

What this trial tests

Phase 3 trial testing Move For Surgery Preconditioning Program using a Wearable Activity Tracker (Fitbit) Intervention Group in Lung Cancer, Nonsmall Cell in 102 participants. Completed in 1 June 2022.

Timeline

15 October 2018

Primary endpoint
1 October 2021

1 June 2022

Quick facts

Lead sponsor	St. Joseph's Healthcare Hamilton
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	102
Start date	15 October 2018
Primary completion	1 October 2021
Estimated completion	1 June 2022
Sites	1 location across Canada

Drugs / interventions tested

• Move For Surgery Preconditioning Program using a Wearable Activity Tracker (Fitbit) Intervention Group

Conditions studied

• Lung Cancer, Nonsmall Cell — all drugs for Lung Cancer, Nonsmall Cell →

Sponsor

St. Joseph's Healthcare Hamilton — full company profile →

Who can join

18 and older, any sex, with Lung Cancer, Nonsmall Cell. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lung cancer is the leading cause of cancer death in Canada. Most patients with this cancer will undergo treatment with major chest surgery that is associated with serious complications. As many as 50% of patients will suffer respiratory complications after surgery, keeping them in the hospital for extended periods of time. These long hospitalizations have a dramatic negative effect on the lives of those people, in addition to a large cost burden on our healthcare system. Traditionally, patients who suffer from complications are treated with rehabilitation AFTER the complications have occurred. But what if complications can be prevented BEFORE they happen? Having major chest surgery imposes great stress on the human body, one that is equivalent to running a marathon. Analogous to training before completing a marathon, the investigator designed Move For Surgery (MFS), a novel preconditioning program that encourages and empowers patients to improve their health prior to surgery. The investigator aims to demonstrate that patients who train with Move For Surgery will have lower respiratory complication rates, will recover better, and will leave the hospital sooner than their counterparts.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Application of wearables for remote monitoring of oncology patients: A scoping review.
   Cloß K, Verket M, Müller-Wieland D, Marx N, et al · · 2024 · cited 16× · PMID 38481796 · DOI 10.1177/20552076241233998
2. Preconditioning program reduces the incidence of prolonged hospital stay after lung cancer surgery: Results from the Move For Surgery randomized clinical trial.
   Patel YS, Sullivan KA, Churchill IF, Beauchamp MK, et al · · 2023 · cited 12× · PMID 37643916 · DOI 10.1093/bjs/znad252
3. Postoperative outcomes of preoperative exercise training in patients with operable non-small cell lung cancer: a systematic review and meta-analysis.
   Li C, Meng H, Wei Y, Liang Y, et al · · 2025 · PMID 41018094 · DOI 10.3389/fonc.2025.1563478