Who is sponsoring NCT03687502?

NCT03687502 is sponsored by Children's Mercy Hospital Kansas City.

What drugs are being tested in NCT03687502?

Interventions in NCT03687502: Sulfur hexafluoride lipid-type A microspheres.

What condition does NCT03687502 study?

NCT03687502 studies Acute Appendicitis.

Is NCT03687502 still recruiting?

NCT03687502 is currently completed. Last updated 8 September 2023.

Are results published for NCT03687502?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2023-09-08 · How we verify

NCT03687502

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Role of Contrast Enhanced Ultrasound in Appendicitis

Completed Phase 2 Results posted Last updated 8 September 2023

What this trial tests

Phase 2 trial testing Sulfur hexafluoride lipid-type A microspheres in Acute Appendicitis in 37 participants. Completed in 5 July 2022.

Timeline

4 January 2019

Primary endpoint
26 March 2021

5 July 2022

Quick facts

Lead sponsor	Children's Mercy Hospital Kansas City
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	37
Start date	4 January 2019
Primary completion	26 March 2021
Estimated completion	5 July 2022
Sites	1 location across United States

Drugs / interventions tested

Sulfur hexafluoride lipid-type A microspheres — full drug profile →

Conditions studied

Acute Appendicitis — all drugs for Acute Appendicitis →

Sponsor

Children's Mercy Hospital Kansas City

Who can join

Adults 8 to 17, any sex, with Acute Appendicitis. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Children With an Accurate Diagnosis of Appendicitis. Primary · 1 week

Number of children with an accurate diagnosis of appendicitis when compared to the standard grey scale ultrasound and/ or CT scan based on the following categories: Category 1: Normal appendix Category 2: Appendix not fully visualized without secondary signs Category 3: Appendix not fully visualized with secondary signs Category 4: Appendicitis

Group	Value	95% CI
Contrast Enhanced Ultrasound Group	6
Contrast Enhanced Ultrasound Group	15
Contrast Enhanced Ultrasound Group	1
Contrast Enhanced Ultrasound Group	13

Definitive Diagnosis Secondary · 1 week

Proportion of children with definitive diagnosis of appendicitis with use of CEUS.

Group	Value	95% CI
Contrast Enhanced Ultrasound Group	13

Number of Participants Who Required Additional CT Scan Secondary · 30 days

"Number of Participants who Required Additional CT Scan"

Group	Value	95% CI
Experimental	0

Percentage of Negative Appendectomies Secondary · 1 week

Percentage of negative appendectomies

Group	Value	95% CI
Contrast Enhanced Ultrasound Group	1

Total Cost Difference Compared to Traditional Ultrasound Secondary · 60 days

Costs in comparison to traditional ultrasound

Group	Value	95% CI
Contrast Enhanced Ultrasound Group	16

Total Cost Difference Between Traditional Ultrasound in Comparison to Costs in CT Scan. Secondary · 60 days

Comparing total costs difference between traditional ultrasound in comparison to costs in CT scan. Total CT Scan Costs - Total Ultrasound Costs = Cost Difference.

Group	Value	95% CI
Contrast Enhanced Ultrasound Group	6198

Sponsor's own description

This study seeks to determine the efficacy of Contrast Enhanced Ultrasound (CEUS) in improving the diagnosis of acute appendicitis in children, when compared to the standard grey-scale ultrasound.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Sulfur hexafluoride lipid-type A microspheres

Trials testing the same drug.

NCT04640038 — Contrast Enhanced Ultrasound in COVID-19 · Phase 3 · completed
NCT03549520 — CEUS Evaluation of Hypoxic Ischemic Injury · Phase 3 · completed
NCT03549507 — CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis · Phase 3 · terminated
NCT03295656 — Contrast-Enhanced Ultrasound Diagnosis of Acute Appendicitis · Phase 1 · withdrawn

Other recruiting trials for Acute Appendicitis

Currently open trials in the same condition.

NCT07496723 — Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis · recruiting
NCT07008092 — Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children · recruiting
NCT07492329 — Antibiotics vs Surgery in Acute Appendicitis · NA · active not recruiting
NCT06563349 — Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy · Phase 4 · recruiting
NCT03236961 — Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis · NA · active not recruiting

Other Children's Mercy Hospital Kansas City trials

Trials by the same sponsor.

NCT07458568 — ViBandz Feasibility Study · not yet recruiting
NCT07195032 — Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients · Phase 4 · recruiting
NCT06834594 — Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome · Phase 4 · recruiting
NCT06738121 — Cosmetic Outcomes of Umbilical Hernia Incisions · NA · completed
NCT06520657 — Addressing Social Determinants of Health in Child Obesity Treatment Using Community Health Workers · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03687502 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Children's Mercy Hospital Kansas City
Last refreshed: 8 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03687502.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing