NCT03672448

The China Longitudinal Aging Study of Cognitive Impairment

Status unknown Last updated 10 January 2020

What this trial tests

trial testing Naturalistic observation in Mild Cognitive Impairment in 10,000 participants. Status unknown.

Timeline

1 September 2018

Primary endpoint
30 November 2023

30 November 2023

Quick facts

Lead sponsor	Shanghai Mental Health Center
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	10,000
Start date	1 September 2018
Primary completion	30 November 2023
Estimated completion	30 November 2023
Sites	1 location across China

Drugs / interventions tested

• Naturalistic observation

Conditions studied

• Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
• Alzheimer Disease — all drugs for Alzheimer Disease →
• Dementia, Vascular — all drugs for Dementia, Vascular →
• Dementia With Lewy Bodies — all drugs for Dementia With Lewy Bodies →

Sponsor

Shanghai Mental Health Center — full company profile →

Who can join

60 and older, any sex, with Mild Cognitive Impairment or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. Based on the above understanding, the study carry out the population cohort study based on accurate diagnosis and construct the high standard information and sample bank. The study will establish the standard and quality system of geriatric cognitive disorders cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of elderly cognitive disorders, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study will evaluate whether peripheral nerve degeneration can predict central nervous system degeneration based on the large cohort of elderly study. In addition, The study will make an effective supplement the sample bank construction of Shanghai Mental Health Center.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Morphological, Structural, and Functional Networks Highlight the Role of the Cortical-Subcortical Circuit in Individuals With Subjective Cognitive Decline.
   Xu X, Wang T, Li W, Li H, et al · · 2021 · cited 23× · PMID 34305568 · DOI 10.3389/fnagi.2021.688113
2. Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.
   Wang T, He H, Shi Y, Su N, et al · · 2025 · cited 3× · PMID 40070969 · DOI 10.1136/gpsych-2024-101736