Last reviewed · How we verify
NCT03666780: LISA
Lifetech LAmbre™ Left Atrial Appendage (LAA) Closure System Post-Market Clinical Follow-up Study
trial testing LAmbre Occluder in Atrial Fibrillation in 500 participants. Completed in 30 September 2024.
29 November 2021
Quick facts
| Lead sponsor | Lifetech Scientific (Shenzhen) Co., Ltd. |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 16 November 2018 |
| Primary completion | 29 November 2021 |
| Estimated completion | 30 September 2024 |
| Sites | 26 locations across Denmark, Italy, Sweden, Ireland, Germany, Poland, Thailand, China |
Drugs / interventions tested
- LAmbre Occluder
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
Sponsor
Lifetech Scientific (Shenzhen) Co., Ltd. — full company profile →
Who can join
18 and older, any sex, with Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Multi-center, single-arm, prospective, post-market study of LAmbre™ LAA Closure System. To evaluate the immediate and long-term procedural success of Lifetech LAmbre™ occluders in patients.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Left atrial appendage closure for stroke prevention in atrial fibrillation: current status and perspectives.
Landmesser U, Skurk C, Tzikas A, Falk V, et al · · 2024 · cited 37× · PMID 39027946 · DOI 10.1093/eurheartj/ehae398 -
Left Atrial Appendage Closure: A Narrative Review.
Nagasaka T, Nakamura M. · · 2023 · cited 8× · PMID 37938523 · DOI 10.1007/s40119-023-00337-2
Verify or expand the search:
- PubMed search for NCT03666780
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrial Fibrillation
Currently open trials in the same condition.
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- NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
- NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
- NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
Other Lifetech Scientific (Shenzhen) Co., Ltd. trials
Trials by the same sponsor.
- NCT07385599 — FIM Study of the LAmbre™ II LAA Occluder in Non-Valvular AF Patients · NA · active not recruiting
- NCT06915545 — Study on the Aortic Arch Single Branch Stent Graft System · NA · recruiting
- NCT06849635 — Cera™ ASD Occluder Post-Market Clinical Follow-Up Study · recruiting
- NCT06700174 — Lifetech AcuMark™ Sizing Balloon Post-Market Clinical Follow-up Study · recruiting
- NCT06520774 — Concave Supra-arch Branched Stent-Graft System for Endovascular Treatment of Aortic Arch Diseases · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03666780 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lifetech Scientific (Shenzhen) Co., Ltd.
- Last refreshed: 4 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03666780.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing