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NCT03658421
Dexmedetomidine as Adjuvant for FNB in TKA
NA trial testing Dexmedetomidine in Nerve Block in 90 participants. Completed in 10 November 2018.
5 November 2018
Quick facts
| Lead sponsor | First Affiliated Hospital, Sun Yat-Sen University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 1 September 2018 |
| Primary completion | 5 November 2018 |
| Estimated completion | 10 November 2018 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Dexmedetomidine (dexmedetomidine) — full drug profile →
- ultrasound-guided femoral nerve block
- intravenous patient-controlled analgesia pump with morphine
- Continuous femoral nerve block
Conditions studied
- Nerve Block — all drugs for Nerve Block →
- Dexmedetomidine — all drugs for Dexmedetomidine →
Sponsor
First Affiliated Hospital, Sun Yat-Sen University
Who can join
Adults 50 to 80, any sex, with Nerve Block or Dexmedetomidine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study was to find out whether addition of dexmedetomidine to lower concentration of ropivacaine preoperatively in femoral nerve block (FNB) would intensify analgesia and preserve quadriceps muscle strength after TKA.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Effect Of Dexmedetomidine As Adjuvant To Ropivacaine 0.1% For Femoral Nerve Block On Strength Of Quadriceps Muscle In Patients Undergoing Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial.
Yang X, Kang W, Xiong W, Lu D, et al · · 2019 · cited 13× · PMID 31908520 · DOI 10.2147/jpr.s217283
Verify or expand the search:
- PubMed search for NCT03658421
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dexmedetomidine
Trials testing the same drug.
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- NCT07398066 — DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) · NA · not yet recruiting
- NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
- NCT07306702 — Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients · Phase 4 · withdrawn
- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
Other recruiting trials for Nerve Block
Currently open trials in the same condition.
- NCT07509866 — Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal · NA · recruiting
- NCT07346885 — Lumbar-Sacral Plexus Block vs Fascia Iliaca Block Plus Low-Dose Spinal Anesthesia for Femoral Neck Fracture Surgery · NA · active not recruiting
- NCT07249827 — A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guid · Phase 2 · recruiting
- NCT07239817 — PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach · NA · recruiting
- NCT07510269 — Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on · NA · recruiting
Other First Affiliated Hospital, Sun Yat-Sen University trials
Trials by the same sponsor.
- NCT07322835 — Efficacy and Safety of Reperfusion Therapy for Minor Ischemic Stroke in China · not yet recruiting
- NCT07322848 — DEB-TACE vs cTACE in HCC After TIPS · Phase 3 · recruiting
- NCT07087418 — AI-Driven Multimodal Imaging Integration for Diagnosis and Prognostication of Digestive System Diseases · recruiting
- NCT07014475 — Efficacy of the Ranger Drug-Coated Balloon in Treating BTK Lesions in Patients With CLTI · not yet recruiting
- NCT06951334 — Clinical Trial of Vildagliptin in Early Parkinson's Disease · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03658421 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by First Affiliated Hospital, Sun Yat-Sen University
- Last refreshed: 16 November 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03658421.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing