Adults 12 to 30, any sex, with Crowding of Teeth. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Rate of Mandibular Teeth AlignmentPrimary· From the initiation of the treatment to the completion of alignment stage (approximately 6 months)
tooth movement rate (mm/month) was calculated. From the initiation of the treatment to the completion of alignment stage (approximately 6 months). All tooth movement rate measurements were performed in each month.
first month
Group
Value
95% CI
Micro-osteoperforation
4.27
± 1.75
Conventional Treatment
2.82
± 0.87
second months
Group
Value
95% CI
Micro-osteoperforation
2.08
± 0.91
Conventional Treatment
2.31
± 1.29
third months
Group
Value
95% CI
Micro-osteoperforation
1.94
± 0.99
Conventional Treatment
1.54
± 0.65
fourth months
Group
Value
95% CI
Micro-osteoperforation
0.84
± 0.95
Conventional Treatment
0.89
± 0.49
fifth months
Group
Value
95% CI
Micro-osteoperforation
0.34
± 0.57
Conventional Treatment
0.93
± 0.7
Sponsor's own description
Prolonged orthodontic treatment increases the risc of caries, periodontal problems and root resorption. Many different techniques were developed to shorten the treatment time. The aim of this study was to evaluate the effectiveness of micro-osteoperforations (MOP) performed in the alignment stage.
Twenty eight patients with mandibular arch discrepancy will be included in this research. After the patients are informed about the study they will be requested to sign the consent form.. At the beginning of the treatment routine orthodontic records (photographs, dental models and radiographs) will be taken and the gingival pocket measurements will be made.
The twenty eight patients will be randomly divided in two groups. In the first group, 3 or 4 micro-osteoperforations will be made in the parts of the gingiva nearby the discrepancy by perforating the keratinized or non-keratinized mucosa and reaching the alveolar bone under local anesthesia. In the further appointments the traditional aligning procedures will be used and controls will be made every 7-9 days. In the other group 20 patients will be treated in the traditional way and controls will be made each month. Every patient will be requested to answer questions related to treatment comfort and other problems like pain within the first week after each activations. The records will be repeated after the leveling phase. Tooth movement rate will be calculated according to the measurements made on dental casts. Measurements related to cephalometrics and gingival thickness will be evaluated. The results of two groups will be compared in terms of tooth movement rate, gingival thickness, pain and patient comfort.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
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Sponsor: as reported to ClinicalTrials.gov by Izmir Katip Celebi University
Last refreshed: 3 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03652454.