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NCT03648710
Community Health Workers and mHealth for Sickle Cell Disease Care
NA trial testing Peer Community Health Worker in Sickle Cell Disease in 405 participants. Completed in 31 August 2024.
31 August 2024
Quick facts
| Lead sponsor | Children's Hospital of Philadelphia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 405 |
| Start date | 15 January 2019 |
| Primary completion | 31 August 2024 |
| Estimated completion | 31 August 2024 |
| Sites | 5 locations across United States |
Drugs / interventions tested
- Peer Community Health Worker
- Mobile Health
Conditions studied
- Sickle Cell Disease — all drugs for Sickle Cell Disease →
Sponsor
Children's Hospital of Philadelphia
Who can join
17 and older, any sex, with Sickle Cell Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will compare the effectiveness of two self-management support interventions-Community Health Workers (CHW) and mobile health (mHealth)-versus enhanced usual care to improve health-related quality of life and acute care use for transitioning youth with sickle cell disease (SCD), and identify and quantify mediators and moderators of intervention treatment effects.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
A program of transition to adult care for sickle cell disease.
Saulsberry AC, Porter JS, Hankins JS. · · 2019 · cited 56× · PMID 31808907 · DOI 10.1182/hematology.2019000054 -
Patient navigator programmes for children and adolescents with chronic diseases.
Lalji R, Koh L, Francis A, Khalid R, et al · · 2024 · cited 7× · PMID 39382077 · DOI 10.1002/14651858.cd014688.pub2 -
Community Health Worker and Mobile Health Interventions for Quality of Life Among Young Adults With Sickle Cell Disease: A Randomized Clinical Trial.
Jan S, Steinway C, Belton T, Shults J, et al · · 2025 · cited 1× · PMID 41247734 · DOI 10.1001/jamanetworkopen.2025.43571 -
The Community Health Workers and Mobile Health for Emerging Adults Transitioning Sickle Cell Disease Care (COMETS) Trial: Protocol for a Randomized Controlled Trial.
Belton TD, Steinway CM, Teng O, Shults J, et al · · 2025 · cited 1× · PMID 40905609 · DOI 10.2196/69239 -
Recruitment and retention of young adults with sickle cell disease.
Belton T, Carbaugh L, Stevens E, Seide A, et al · · 2026 · PMID 41869584 · DOI 10.1016/j.hctj.2026.100133
Verify or expand the search:
- PubMed search for NCT03648710
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sickle Cell Disease
Currently open trials in the same condition.
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- NCT06016634 — Alendronate for Osteonecrosis in Adults With Sickle Cell Disease · Phase 2 · recruiting
- NCT06260891 — Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial · Phase 2 · recruiting
- NCT07222475 — Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease · NA · recruiting
- NCT07224360 — Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) · Phase 2 · recruiting
Other Children's Hospital of Philadelphia trials
Trials by the same sponsor.
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- NCT07425691 — SPACE for Youth With Chronic Pain · recruiting
- NCT07444528 — Upper Airway Ultrasound to Predict Difficult Laryngoscopy in Neonates and Infants · enrolling by invitation
- NCT07321327 — Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions: Aim 2 · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03648710 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital of Philadelphia
- Last refreshed: 4 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03648710.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing