Who is sponsoring NCT03644472?

NCT03644472 is sponsored by Penn State University.

What drugs are being tested in NCT03644472?

Interventions in NCT03644472: nitrate rich beetroot juice, nitrate depleted beetroot juice.

What condition does NCT03644472 study?

NCT03644472 studies Postmenopausal Women.

Is NCT03644472 still recruiting?

NCT03644472 is currently completed. Last updated 27 February 2023.

Last reviewed 2023-02-27 · How we verify

NCT03644472

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Postmenopausal Women and Their Endothelium

Completed Phase 2 Last updated 27 February 2023

What this trial tests

Phase 2 trial testing nitrate rich beetroot juice in Postmenopausal Women in 37 participants. Completed in 20 February 2023.

Timeline

7 November 2018

Primary endpoint
20 February 2023

20 February 2023

Quick facts

Lead sponsor	Penn State University
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	37
Start date	7 November 2018
Primary completion	20 February 2023
Estimated completion	20 February 2023
Sites	1 location across United States

Drugs / interventions tested

nitrate rich beetroot juice — full drug profile →
nitrate depleted beetroot juice — full drug profile →

Conditions studied

Postmenopausal Women — all drugs for Postmenopausal Women →

Sponsor

Penn State University

Who can join

Under 70, female only, with Postmenopausal Women. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

A single dose of dietary nitrate supplementation protects against endothelial ischemia-reperfusion injury in early postmenopausal women.
Somani YB, Soares RN, Gosalia J, Delgado JM, et al · · 2022 · cited 15× · PMID 35358395 · DOI 10.1139/apnm-2021-0693
Seven-day dietary nitrate supplementation clinically significantly improves basal macrovascular function in postmenopausal women: a randomized, placebo-controlled, double-blind, crossover clinical trial.
Delgado Spicuzza JM, Gosalia J, Zhong L, Bondonno C, et al · · 2024 · cited 10× · PMID 38915856 · DOI 10.3389/fnut.2024.1359671

Verify or expand the search:

Other Penn State University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03644472 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Penn State University
Last refreshed: 27 February 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03644472.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing