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NCT03638960
Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery
Phase 4 trial testing Bupivacaine liposome in Shoulder Pain in 40 participants. Completed in 6 June 2023.
11 January 2023
Quick facts
| Lead sponsor | University of Southern California |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 21 February 2019 |
| Primary completion | 11 January 2023 |
| Estimated completion | 6 June 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Bupivacaine liposome
- Bupivacaine Hydrochloride (Bupivacaine Hydrochloride) — full drug profile →
Conditions studied
- Shoulder Pain — all drugs for Shoulder Pain →
- Postoperative Pain — all drugs for Postoperative Pain →
Sponsor
University of Southern California
Who can join
18 and older, any sex, with Shoulder Pain or Postoperative Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will be comparing pain scores and opioid use in patients receiving interscalene peripheral blocks with plain bupivacaine versus those receiving liposomal bupivacaine. Liposomal bupivacaine is described as releasing local anesthetic up to 72 hours after its injection; therefore if liposomal bupivacaine can provide extended pain relief compared to plain bupivacaine, the investigators can consider using it as our primary local anesthetic. As secondary outcomes, the investigators will also be looking at difference in functional status and long-term differences between the two local anesthetics.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Interscalene nerve block with plain bupivacaine versus liposomal bupivacaine for arthroscopic rotator cuff repair: A randomized controlled trial.
Lee PS, Mano YM, Hom BM, Bolia IK, et al · · 2025 · cited 3× · PMID 40255349 · DOI 10.4103/sja.sja_44_25
Verify or expand the search:
- PubMed search for NCT03638960
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Bupivacaine liposome
Trials testing the same drug.
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- NCT06653621 — Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Repl · Phase 4 · not yet recruiting
- NCT06452147 — Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform T · NA · recruiting
- NCT06288841 — Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in · NA · unknown
- NCT05992896 — A Study of Loco-Regional Liposomal Bupivacaine Injection · Phase 4 · terminated
Other recruiting trials for Shoulder Pain
Currently open trials in the same condition.
- NCT07493226 — Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis · NA · recruiting
- NCT07493213 — USG-Guided Shoulder Injections in Frozen Shoulder · NA · recruiting
- NCT07424638 — Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain · NA · recruiting
- NCT07394673 — Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery · NA · recruiting
- NCT07334171 — Inspiratory Muscle Strength and Diaphragm Thickness in People With Shoulder Pain in Tennis Players · active not recruiting
Other University of Southern California trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03638960 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern California
- Last refreshed: 15 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03638960.
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