NCT03634462 is a NA clinical trial of CDT with graded negative pressure in Lipedema, sponsored by Vanderbilt University Medical Center.

Who is sponsoring NCT03634462?

NCT03634462 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT03634462?

Interventions in NCT03634462: CDT with graded negative pressure.

What condition does NCT03634462 study?

NCT03634462 studies Lipedema, Secondary Lymphedema.

Is NCT03634462 still recruiting?

NCT03634462 is currently completed. Last updated 19 May 2020.

Last reviewed 2020-05-19 · How we verify

NCT03634462

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy

Completed NA Last updated 19 May 2020

What this trial tests

NA trial testing CDT with graded negative pressure in Lipedema in 10 participants. Completed in 28 February 2020.

Timeline

15 January 2019

Primary endpoint
30 October 2019

28 February 2020

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	15 January 2019
Primary completion	30 October 2019
Estimated completion	28 February 2020
Sites	1 location across United States

Drugs / interventions tested

CDT with graded negative pressure

Conditions studied

Lipedema — all drugs for Lipedema →
Secondary Lymphedema — all drugs for Secondary Lymphedema →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 14 to 90, female only, with Lipedema or Secondary Lymphedema. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is designed to investigate the therapy outcomes from routine physical therapy in persons with lipedema and secondary limb lymphedema. Complete decongestive therapy (CDT) is a common conservative treatment to optimize lymphatic functioning using exercise, compression, lymphatic stimulation and skin care. PhysioTouch is a gentle graded negative pressure device designed to enhance lymphatic stimulation that is used by the skilled therapist in conjunction with hands on techniques of tissue mobilization for enhanced clearance of lymph stasis in persons with lymphedema. This study will investigate the conservative treatment impact in patients with lipedema and lower extremity lymphedema using this conservative available technique.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Physical Therapy in Women with Early Stage Lipedema: Potential Impact of Multimodal Manual Therapy, Compression, Exercise, and Education Interventions.
Donahue PMC, Crescenzi R, Petersen KJ, Garza M, et al · · 2022 · cited 23× · PMID 34748408 · DOI 10.1089/lrb.2021.0039

Verify or expand the search:

Other recruiting trials for Lipedema

Currently open trials in the same condition.

NCT07489248 — Multimodal Ultrasound for Differentiating Lymphedema and Lipedema · recruiting
NCT07468097 — The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational · recruiting
NCT07294014 — Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema · recruiting
NCT07458932 — Evaluation of Physical Activity in Women With Lipedema · recruiting
NCT06558851 — The Effect of Systematic Endurance Training in Treatment of Women With Lipedema · NA · active not recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

NCT07005037 — Swallowing Impairments in ICU Survivors and Community-Dwelling Adults · not yet recruiting
NCT07527273 — Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · NA · not yet recruiting
NCT07295288 — Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis · Phase 4 · not yet recruiting
NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03634462 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 19 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03634462.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing