NCT03607331 is a EARLY_PHASE1 clinical trial of Auricular vagus nerve stimulation in Depression, sponsored by China Academy of Chinese Medical Sciences.

Who is sponsoring NCT03607331?

NCT03607331 is sponsored by China Academy of Chinese Medical Sciences.

What drugs are being tested in NCT03607331?

Interventions in NCT03607331: Auricular vagus nerve stimulation, Citalopram.

What condition does NCT03607331 study?

NCT03607331 studies Depression, Depressive Symptom, Depressive Disorder.

Is NCT03607331 still recruiting?

NCT03607331 is currently status unknown. Last updated 22 April 2019.

Last reviewed 2019-04-22 · How we verify

NCT03607331

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Auricular Concha Electro-acupuncture for the Treatment of Depression

Status unknown EARLY_PHASE1 Last updated 22 April 2019

What this trial tests

EARLY_PHASE1 trial testing Auricular vagus nerve stimulation in Depression in 106 participants. Status unknown.

Timeline

17 September 2018

Primary endpoint
1 July 2019

1 August 2019

Quick facts

Lead sponsor	China Academy of Chinese Medical Sciences
Phase	EARLY_PHASE1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	106
Start date	17 September 2018
Primary completion	1 July 2019
Estimated completion	1 August 2019
Sites	1 location across China

Drugs / interventions tested

Auricular vagus nerve stimulation
Citalopram (CITALOPRAM) — full drug profile →

Conditions studied

Depression — all drugs for Depression →
Depressive Symptom — all drugs for Depressive Symptom →
Depressive Disorder — all drugs for Depressive Disorder →

Sponsor

China Academy of Chinese Medical Sciences — full company profile →

Who can join

Adults 18 to 65, any sex, with Depression or Depressive Symptom. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study was to compare the therapeutic effects of Auricular Concha Electro-acupuncture and Citalopram on patients with major depressive disorder (MDD).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder.
Zhang S, He JK, Zhong GL, Wang Y, et al · · 2022 · cited 10× · PMID 36552189 · DOI 10.3390/brainsci12121730
Mapping the modulating effect of transcutaneous auricular vagus nerve stimulation on voxel-based analyses in patients with first-episode major depressive disorder: a resting-state functional magnetic resonance imaging study.
He JK, Li SY, Wang Y, Zhao B, et al · · 2023 · cited 5× · PMID 37015869 · DOI 10.47626/1516-4446-2022-2788

Verify or expand the search:

Other trials of Auricular vagus nerve stimulation

Trials testing the same drug.

NCT06450483 — Compare the Effects of Different AVNS Parameters on Neck Pain, HRV, Balance in Collegiate Atheletes · NA · recruiting
NCT04971018 — Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Digestive Symptoms in Systemic Sclerosis Systemic Sclerosi · NA · completed
NCT05436821 — The Effect of Vagus Nerve Stimulation on Sportive Performance. · NA · completed

Other recruiting trials for Depression

Currently open trials in the same condition.

NCT07336238 — Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or · Phase 2 · recruiting
NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT07517549 — Sexual Health Education During Pregnancy · NA · recruiting
NCT06408246 — ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression · Phase 2 · recruiting
NCT07449676 — Effects of an Innovative TCM-based Tui Jing Therapy on Psychological and Neurophysiological Functions in Depression · NA · recruiting

Other China Academy of Chinese Medical Sciences trials

Trials by the same sponsor.

NCT07319338 — Objective Vascular Biomarkers as Triage for Depression in Chronic Atrophic Gastritis · not yet recruiting
NCT06874738 — A Real-world Clinical Study on the Treatment of Menopausal Syndrome With Liuwei Dihuang Pills · not yet recruiting
NCT05586048 — Effectiveness of Yiqi Fumai Lyophilized Injection for Acute Heart Failure · unknown
NCT05138965 — the Method of Cotton Padding Promoting the Rectovaginal Fistula Surgery · completed
NCT04932395 — Anshen Buxin Liuwei Pills for the Treatment of Cardiac Neurosis · Phase 4 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03607331 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by China Academy of Chinese Medical Sciences
Last refreshed: 22 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03607331.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing