NCT03606434 is a NA clinical trial of Hypoxic exposure in Healthy Participants, sponsored by University of Missouri-Columbia.

Who is sponsoring NCT03606434?

NCT03606434 is sponsored by University of Missouri-Columbia.

What drugs are being tested in NCT03606434?

Interventions in NCT03606434: Hypoxic exposure.

What condition does NCT03606434 study?

NCT03606434 studies Healthy Participants.

Is NCT03606434 still recruiting?

NCT03606434 is currently completed. Last updated 21 July 2021.

Last reviewed 2021-07-21 · How we verify

NCT03606434

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sex Differences in Reflex Responses to Intermittent Hypoxia

Completed NA Last updated 21 July 2021

What this trial tests

NA trial testing Hypoxic exposure in Healthy Participants in 40 participants. Completed in 15 July 2021.

Timeline

13 September 2018

Primary endpoint
15 July 2021

15 July 2021

Quick facts

Lead sponsor	University of Missouri-Columbia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	40
Start date	13 September 2018
Primary completion	15 July 2021
Estimated completion	15 July 2021
Sites	1 location across United States

Drugs / interventions tested

Hypoxic exposure

Conditions studied

Healthy Participants — all drugs for Healthy Participants →

Sponsor

University of Missouri-Columbia

Who can join

Adults 18 to 45, any sex, with Healthy Participants. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of the present study is to determine whether there are sex differences in the reflex responses to hypoxia in humans.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.
Jacob DW, Harper JL, Ivie CL, Ott EP, et al · · 2021 · cited 17× · PMID 34187092 · DOI 10.1113/ep089461
Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.
Mascone SE, Jacob DW, Eagan LE, Harper JL, et al · · 2023 · cited 5× · PMID 37878751 · DOI 10.1113/ep091394
The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.
Jacob DW, Morgenthaler LD, Harper JL, Limberg JK. · · 2023 · cited 3× · PMID 37410902 · DOI 10.1152/japplphysiol.00760.2022

Verify or expand the search:

Other trials of Hypoxic exposure

Trials testing the same drug.

NCT03659825 — Ketone Esters for Optimization of Cognitive Performance in Hypoxia · NA · unknown
NCT05146089 — Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences · EARLY_PHASE1 · completed

Other recruiting trials for Healthy Participants

Currently open trials in the same condition.

NCT07469085 — A Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SV003 in Healthy Partici · Phase 1 · recruiting
NCT07503990 — Effects of Food Intake Sequence on Substrate Utilisation and Endurance Performance · NA · recruiting
NCT07474987 — Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury · recruiting
NCT07511205 — A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participa · Phase 1 · recruiting
NCT07448155 — A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of INCA033989 Following Subcutaneous or Intravenous A · Phase 1 · active not recruiting

Other University of Missouri-Columbia trials

Trials by the same sponsor.

NCT07478172 — Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease · NA · recruiting
NCT07385105 — Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI) · NA · not yet recruiting
NCT07067502 — Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations · NA · not yet recruiting
NCT07424079 — Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy · NA · not yet recruiting
NCT07216196 — The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03606434 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Missouri-Columbia
Last refreshed: 21 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03606434.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing