NCT03600454 (MUSCLE) is a NA clinical trial of General anesthesia in Muscle Weakness, sponsored by Ziekenhuis Oost-Limburg.

Who is sponsoring NCT03600454?

NCT03600454 is sponsored by Ziekenhuis Oost-Limburg.

What drugs are being tested in NCT03600454?

Interventions in NCT03600454: General anesthesia, Spinal anesthesia, General anesthesia and epidural analgesia.

What condition does NCT03600454 study?

NCT03600454 studies Muscle Weakness, Anesthesia, Anesthesia, Local, Surgery.

Is NCT03600454 still recruiting?

NCT03600454 is currently completed. Last updated 7 January 2020.

Last reviewed 2020-01-07 · How we verify

NCT03600454: MUSCLE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response

Completed NA Last updated 7 January 2020

What this trial tests

NA trial testing General anesthesia in Muscle Weakness in 50 participants. Completed in 30 December 2019.

Timeline

1 September 2018

Primary endpoint
18 December 2019

30 December 2019

Quick facts

Lead sponsor	Ziekenhuis Oost-Limburg
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	50
Start date	1 September 2018
Primary completion	18 December 2019
Estimated completion	30 December 2019
Sites	1 location across Belgium

Drugs / interventions tested

General anesthesia — full drug profile →
Spinal anesthesia — full drug profile →
General anesthesia and epidural analgesia — full drug profile →

Conditions studied

Muscle Weakness — all drugs for Muscle Weakness →
Anesthesia — all drugs for Anesthesia →
Anesthesia, Local — all drugs for Anesthesia, Local →
Surgery — all drugs for Surgery →

Sponsor

Ziekenhuis Oost-Limburg — full company profile →

Who can join

18 and older, any sex, with Muscle Weakness or Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness. The neuro-endocrine stress response could be involved in the pathophysiology. Whether the mode of anesthesia/analgesia can influence muscle weakness, by influencing the neuro-endocrine stress response is unknown. Gaining insight in this matter could affect quality of care and benefit patient recovery and satisfaction.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The effect of spinal versus general anaesthesia on perioperative muscle weakness in patients having bilateral total hip arthroplasty: a single center randomized clinical trial.
Van Boxstael S, Peene L, Dylst D, Penders J, et al · · 2023 · cited 4× · PMID 37864209 · DOI 10.1186/s40001-023-01435-6

Verify or expand the search:

Other trials of General anesthesia

Trials testing the same drug.

NCT07324863 — Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults · NA · recruiting
NCT07074730 — General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty · NA · recruiting
NCT06930183 — Awake Thoracic Epidural Anesthesia Versus General Anesthesia in Thoracotomy · NA · recruiting
NCT06984874 — Erector Spinae Plane Block for Children Undergoing Thoracoscopic Sympathectomy · NA · recruiting
NCT06889987 — Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Pla · NA · recruiting

Other recruiting trials for Muscle Weakness

Currently open trials in the same condition.

NCT06998134 — Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults · recruiting
NCT07103499 — Abdominal and Core Exercises on Respiratory Functions in Obese and Overweight Women (COREBREATH) · NA · recruiting
NCT07292311 — Reliability of Muscle Strength and Activation Assessment Tools and Effects of an Online Therapeutic Exercise Program in · NA · active not recruiting
NCT07026084 — Effects of Biofeedback-Guided Training on Muscle Strength and Postural Alignment in Upper Cross Syndrome. · NA · recruiting
NCT06205147 — Effects of Elastic Band Resistance Exercise on Muscle Strength and Depression in Hospitalized Elderly. · NA · recruiting

Other Ziekenhuis Oost-Limburg trials

Trials by the same sponsor.

NCT07281534 — Test-Retest Reliability of Cardiopulmonary Exercise Testing With Echocardiography · NA · recruiting
NCT07123818 — AI for Detection of Brain Aneurysm: Low-cost Opportunistic Screening · NA · active not recruiting
NCT06994091 — Imaging Comparison for the Preoperative Planning and Diagnosis of DIE: a Multicenter Retrospective Study. · not yet recruiting
NCT06185608 — The Effects of Various Concentrations of Ropivacaine on the Onset and Duration of Ankle Blocks · NA · recruiting
NCT06810479 — A Study Comparing Two Mandibular Advancement Devices in the Treatment of Sleep Apnea · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03600454 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ziekenhuis Oost-Limburg
Last refreshed: 7 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03600454.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing