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Spinal Anesthesia
Spinal anesthesia blocks nerve conduction in the spinal cord by injecting local anesthetic agents into the cerebrospinal fluid, producing rapid onset regional anesthesia of the lower body.
Spinal anesthesia blocks nerve conduction in the spinal cord by injecting local anesthetic agents into the cerebrospinal fluid, producing rapid onset regional anesthesia of the lower body. Used for Lower abdominal and pelvic surgery, Lower extremity orthopedic surgery, Cesarean section.
At a glance
| Generic name | Spinal Anesthesia |
|---|---|
| Also known as | Neuraxial block, Spinal anaesthesia |
| Sponsor | Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
| Drug class | Local anesthetic (regional anesthesia technique) |
| Target | Voltage-gated sodium channels in nerve membranes |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Local anesthetic drugs (such as bupivacaine, lidocaine, or procaine) are injected into the subarachnoid space, where they diffuse into nerve roots and block sodium channels in sensory and motor nerves. This produces reversible loss of sensation and motor function in the lower extremities and lower abdomen, making it suitable for surgical procedures below the umbilicus. The effect is rapid (within minutes) and duration depends on the specific agent and dose used.
Approved indications
- Lower abdominal and pelvic surgery
- Lower extremity orthopedic surgery
- Cesarean section
- Urological procedures
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Nausea
- Urinary retention
- Neurological complications (rare)
Key clinical trials
- Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure (NA)
- Ultrasound Assessment of Femoral Vein and Inferior Vena Cava Collapsibility to Predict Spinal Anesthesia-Induced Hypotension
- "Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section" (NA)
- Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency (PHASE2)
- Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotension in Preeclamptic Parturients
- Evaluation Of Cost-Effectiveness Of Iliac Branch Endoprostheses
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Spinal Anesthesia CI brief — competitive landscape report
- Spinal Anesthesia updates RSS · CI watch RSS
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital portfolio CI