NCT03597334: ATICU

Aerosol Therapy in Intensive Care Units

Completed Last updated 4 December 2018

What this trial tests

trial testing aerosol therapy in Respiration, Artificial in 1,095 participants. Completed in 10 August 2018.

Timeline

9 July 2018

Primary endpoint
5 August 2018

10 August 2018

Quick facts

Lead sponsor	lvshan
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,095
Start date	9 July 2018
Primary completion	5 August 2018
Estimated completion	10 August 2018
Sites	1 location across China

Drugs / interventions tested

• aerosol therapy

Conditions studied

• Respiration, Artificial — all drugs for Respiration, Artificial →
• Critical Care — all drugs for Critical Care →

Sponsor

lvshan

Who can join

Eligibility, any sex, with Respiration, Artificial or Critical Care. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Unlike in the outpatient setting, delivery of aerosols to ICU patients may be considered complex, particularly in ventilated patients. Successful delivery of aerosolized medications to ICU patients depends upon the selection of the aerosol device and its installation position, the humidification condition, and the adjustment of the ventilator mode and parameters, etc. And there is currently little guidance or information on standards of practice in aerosol therapy.

Purpose:The aim of the present work was to assess the frequency, modalities of aerosol therapy in critically ill patients either breathing spontaneously or undergoing invasive or noninvasive ventilation.

Method:This prospective cross-sectional point prevalence study will be carried out over 14 days in several intensive care units. Centers are recruited on a voluntary basis.

During the study period, characteristics of each ICU patient will be prospectively recorded each day. If patients receive inhaled medication during the study period, extensive data such as the selection of the aerosol device and its installation position will be recorded.

Data will be entered into a database and analyses will be performed using SPSS soft ware. A p value lower than 0.05 is considered significant.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The utilization of aerosol therapy in mechanical ventilation patients: a prospective multicenter observational cohort study and a review of the current evidence.
   Lyu S, Li J, Yang L, Du X, et al · · 2020 · cited 17× · PMID 33145290 · DOI 10.21037/atm-20-1313