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NCT03597061

Healthy Start to Feeding Intervention

Completed NA Results posted Last updated 10 May 2023
What this trial tests

NA trial testing Healthy Start to Feeding in Weight, Body in 34 participants. Completed in 19 May 2020.

Timeline
1 November 2018
Primary endpoint
19 May 2020
19 May 2020

Quick facts

Lead sponsorUniversity of Cincinnati
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposeprevention
Enrollment34
Start date1 November 2018
Primary completion19 May 2020
Estimated completion19 May 2020
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

University of Cincinnati

Who can join

Adults 3 Months to 10 Months, any sex, with Weight, Body or Diet Habit. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Weight-for-Length Percentile Primary · Weight and length were measured at both pre-treatment (when infant was 3 months of age) and post-treatment (when infant was 9 months of age).

Infant anthropometrics of weight and length were measured and used to calculate weight-for-length percentile standardized for age and gender.

Pre-treatment
GroupValue95% CI
Healthy Start to Feeding Intervention44.94± 30.25
Control46.70± 26.97
Post-treatment
GroupValue95% CI
Healthy Start to Feeding Intervention58.69± 31.78
Control48.54± 30.82
Appetite Regulation Primary · The BEBQ was completed at both pre-treatment (when infant is 3 months of age) and post-treatment (when infant is 9 months of age).

Infant satiety and food responsiveness was measured using the parent-report Baby Eating Behavior Questionnaire (BEBQ). The BEBQ provides subscale scores for "Food Responsiveness", "Enjoyment of Food", "Satiety Responsiveness", and "Slowness in Eating" with each subscale score ranging from 1 to 5, with 5 representing higher values on that construct. Each subscale score is computed as the average of all individual items on that subscales.

Pre-treatment: Food Responsiveness
GroupValue95% CI
Healthy Start to Feeding Intervention2.96± .33
Control3.01± .24
Pre-treatment: Enjoyment of Food
GroupValue95% CI
Healthy Start to Feeding Intervention3.61± .27
Control3.72± .35
Pre-treatment: Satiety Responsiveness
GroupValue95% CI
Healthy Start to Feeding Intervention1.92± .49
Control1.85± .30
Pre-treatment: Slowness in Eating
GroupValue95% CI
Healthy Start to Feeding Intervention2.59± .48
Control2.73± .48
Post-treatment: Food Responsiveness
GroupValue95% CI
Healthy Start to Feeding Intervention2.82± .46
Control2.97± .29
Post-treatment: Enjoyment of Food
GroupValue95% CI
Healthy Start to Feeding Intervention3.70± .26
Control3.58± .24
Post-treatment: Satiety Responsiveness
GroupValue95% CI
Healthy Start to Feeding Intervention1.54± .45
Control1.96± .36
Post-treatment: Slowness in Eating
GroupValue95% CI
Healthy Start to Feeding Intervention2.41± .41
Control2.58± .35
Fruit and Vegetable Variety Primary · The Block Food Frequency Questionnaire was completed at both pre-treatment (when infant is 3 months of age) and post-treatment (when infant is 9 months of age).

Fruit and vegetable variety was assessed using the parent-report Block Food Frequency Questionnaire. Scores were calculated for servings of vegetables per day and servings of fruits per day. The minimum value is 0. There is no upper-bound for the maximum value, as this is dependent on the individual participant's food consumption. Higher numbers indicate greater consumption. Only post-treatment results are presented since infants had not been introduced to solid foods at the time of baseline.

Post-treatment: Fruit Servings Per Day
GroupValue95% CI
Healthy Start to Feeding Intervention1.86± 1.19
Control2.19± 1.11
Post-treatment: Veggie Servings Per Day
GroupValue95% CI
Healthy Start to Feeding Intervention4.92± 3.63
Control5.10± 3.75
Family Satisfaction - Defined as Appropriateness of the Intervention Content and Session Timing, Clarity of Information, Knowledge of the Recommendations, Helpfulness, and Whether They Would Recommend the Intervention to Others. Secondary · The measure of family satisfaction will be completed at post-treatment (when the child is 9 months of age).

Caregivers in the treatment condition completed a survey measuring whether parents found the intervention appropriate for their infant, whether sessions occurred at the right time, whether information was presented clearly, whether they knew how to implement the recommendations, whether the intervention was helpful, whether they were satisfied with the intervention, and whether they would recommend the intervention to a friend/family member/coworker. Each satisfaction attribute will be assessed on a 1-5 Likert scale with higher scores indicating higher agreement. Information from each individu

Appropriateness
GroupValue95% CI
Healthy Start to Feeding Intervention4.60± 1.06
Timing
GroupValue95% CI
Healthy Start to Feeding Intervention4.47± 1.13
Clarity
GroupValue95% CI
Healthy Start to Feeding Intervention4.67± 1.05
Implementation
GroupValue95% CI
Healthy Start to Feeding Intervention4.67± 1.05
Helpful
GroupValue95% CI
Healthy Start to Feeding Intervention4.53± .83
Satisfication
GroupValue95% CI
Healthy Start to Feeding Intervention4.47± 1.25
Would Recommend
GroupValue95% CI
Healthy Start to Feeding Intervention4.47± 1.19
Treatment Attendance Secondary · Attendance of sessions at study month 2 (session 1), study month 4 (session 2), and study month 7 (session 3) was recorded. The number of sessions that each participant attended was calculated.

Treatment attendance was tracked for each family.

Attended Session 1
GroupValue95% CI
Healthy Start to Feeding Intervention16
Attended Session 2
GroupValue95% CI
Healthy Start to Feeding Intervention16
Attended Session 3
GroupValue95% CI
Healthy Start to Feeding Intervention16

Sponsor's own description

The current study will test the impact of a 3-session obesity prevention program targeting healthy introduction of solid foods in infancy on growth trajectories, appetite regulation, and diet. The investigators will also test the feasibility and family satisfaction with the treatment. Healthy infants with normal and elevated weight-for-length will be enrolled in the study at 3 months of age and complete an initial study visit to assess baseline anthropometrics,demographics, parental feeding practices and beliefs, and infant appetite. Infants will than be randomly assigned to either the treatment condition (n = 20) or control condition (n = 20). Infants in the control condition will receive no intervention or further contact with the study team besides for completion of a final study assessment visit when the child is 9 months old. Infants in the treatment condition will receive a 3 session intervention targeting healthy introduction of solid foods, with study visits occurring when the child is 4 months, 6 months, and 9 months old. All families will complete a final study visit to complete post-treatment period measurements, which will include infant anthropometrics and parent-report of infant appetite, infant diet, and parental feeding practices and beliefs. Outcomes include: weight-for-length percentile, infant satiety responsiveness, infant food responsiveness, and infant fruit and vegetable consumption. Family satisfaction and treatment attendance will also be assessed.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Interventions for increasing fruit and vegetable consumption in children aged five years and under.
    Hodder RK, O'Brien KM, Tzelepis F, Wyse RJ, et al · · 2020 · cited 63× · PMID 32449203 · DOI 10.1002/14651858.cd008552.pub7
  2. Interventions for increasing fruit and vegetable consumption in children aged five years and under.
    Hodder RK, O'Brien KM, Stacey FG, Tzelepis F, et al · · 2019 · cited 10× · PMID 31697869 · DOI 10.1002/14651858.cd008552.pub6
  3. Parent-focused behavioural interventions for the prevention of early childhood obesity (TOPCHILD): a systematic review and individual participant data meta-analysis.
    Hunter KE, Nguyen D, Libesman S, Williams JG, et al · · 2025 · cited 3× · PMID 40945528 · DOI 10.1016/s0140-6736(25)01144-4

Verify or expand the search:

Other recruiting trials for Weight, Body

Currently open trials in the same condition.

Other University of Cincinnati trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03597061.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing