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NCT03588910

Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription

Completed Phase 2 Results posted Last updated 13 August 2021
What this trial tests

Phase 2 trial testing Acetaminophen in Surgery in 120 participants. Completed in 4 August 2019.

Timeline
8 August 2018
Primary endpoint
4 July 2019
4 August 2019

Quick facts

Lead sponsorMontefiore Medical Center
PhasePhase 2
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposetreatment
Enrollment120
Start date8 August 2018
Primary completion4 July 2019
Estimated completion4 August 2019
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Montefiore Medical Center

Who can join

18 and older, female only, with Surgery. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Oxycodone Tablets Used Day 1 Primary · 24 hours post-operative

During the survey phone call on day 1, participants will be asked to report the total number of oxycodone tablets use since the surgery.

GroupValue95% CI
Number of Oxycodone Tablets Typically Prescribed1.00.0 – 1.0
Half the Number of Oxycodone Tablets Typically Prescribed1.00.0 – 1.0
Number of Oxycodone Tablets Used as Reported by Participants 1 Week After Surgery Primary · 7 days post-operative

During the survey phone call on day 7, participants will be asked to report the total number of oxycodone tablets used since the surgery.

GroupValue95% CI
Number of Oxycodone Tablets Typically Prescribed2.50.0 – 5.0
Half the Number of Oxycodone Tablets Typically Prescribed2.00.0 – 4.0
Self Reported Pain Score on Post Operative Day 1 (Numeric Pain Reporting Score: NRS) Secondary · 1 day post operative

Participants will be surveyed during the phone call survey to rate pain score on a scale from 0 (no pain), to 10 (severe pain)

GroupValue95% CI
Number of Oxycodone Tablets Typically Prescribed5.03.0 – 7.0
Half the Number of Oxycodone Tablets Typically Prescribed52.0 – 6.0
Self Reported Pain Score on Post Operative Day 7 (Numeric Pain Reporting Score: NRS) Secondary · 7 days post operative

Participants will be surveyed during the phone call survey to rate pain score on a scale from 0 (no pain), to 10 (severe pain)

GroupValue95% CI
Number of Oxycodone Tablets Typically Prescribed2.00.0 – 4.0
Half the Number of Oxycodone Tablets Typically Prescribed1.30.0 – 3.3
Additional Contacts With Provider Secondary · 1 week post operative

By chart review, unscheduled interactions with the healthcare system related to pain will be counted.These will include phone calls related to pain, unscheduled visits to the office or emergency department

GroupValue95% CI
Number of Oxycodone Tablets Typically Prescribed1
Half the Number of Oxycodone Tablets Typically Prescribed4

Sponsor's own description

Currently there is a nationwide epidemic in opioid abuse and overdose deaths. While the opioid epidemic is multi-factorial one major source of excess opioids may be over-prescribing in the post-operative period. There is wide variation in the prescribing practices for post-operative pain control and there is no standard of care for pain control after minor laparoscopic surgery in general or after gynecologic laparoscopy. There is also evidence to show that on average half of the opioids prescribed are unused by the patient. The aim of the study is to evaluate two opioid prescription regimens.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Acetaminophen

Trials testing the same drug.

Other recruiting trials for Surgery

Currently open trials in the same condition.

Other Montefiore Medical Center trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03588910.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing