NCT03588351 is a NA clinical trial of chitosan nanoparticles gel in Necrotic Pulp, sponsored by Ain Shams University.

Who is sponsoring NCT03588351?

NCT03588351 is sponsored by Ain Shams University.

What drugs are being tested in NCT03588351?

Interventions in NCT03588351: chitosan nanoparticles gel, chitosan gel, chlorhexidine gluconate.

What condition does NCT03588351 study?

NCT03588351 studies Necrotic Pulp.

Is NCT03588351 still recruiting?

NCT03588351 is currently status unknown. Last updated 17 July 2018.

Last reviewed 2018-07-17 · How we verify

NCT03588351

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

Status unknown NA Last updated 17 July 2018

What this trial tests

NA trial testing chitosan nanoparticles gel in Necrotic Pulp in 45 participants. Status unknown.

Timeline

1 January 2018

Primary endpoint
15 August 2018

30 August 2018

Quick facts

Lead sponsor	Ain Shams University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	45
Start date	1 January 2018
Primary completion	15 August 2018
Estimated completion	30 August 2018
Sites	1 location across Egypt

Drugs / interventions tested

chitosan nanoparticles gel — full drug profile →
chitosan gel — full drug profile →
chlorhexidine gluconate — full drug profile →

Conditions studied

Necrotic Pulp — all drugs for Necrotic Pulp →

Sponsor

Ain Shams University

Who can join

Adults 4 to 7, any sex, with Necrotic Pulp. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aim of the present study is to assess the in vivo susceptibility of root canal bacteria to Chitosan,Chitosan nanoparticles ,and Chlorhexidine gluconate when used as intra canal medicaments in necrotic primary molars

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Nanocarriers for the Delivery of Medical, Veterinary, and Agricultural Active Ingredients.
Chariou PL, Ortega-Rivera OA, Steinmetz NF. · · 2020 · cited 101× · PMID 32125825 · DOI 10.1021/acsnano.0c00173
Chitosan alchemy: transforming tissue engineering and wound healing.
Pramanik S, Aggarwal A, Kadi A, Alhomrani M, et al · · 2024 · cited 31× · PMID 38887635 · DOI 10.1039/d4ra01594k
Chitosan-based formulations for therapeutic applications. A recent overview.
Gonciarz W, Balcerczak E, Brzeziński M, Jeleń A, et al · · 2025 · cited 28× · PMID 40629425 · DOI 10.1186/s12929-025-01161-7
Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
Nieto González N, Obinu A, Rassu G, Giunchedi P, et al · · 2021 · cited 22× · PMID 34066953 · DOI 10.3390/pharmaceutics13050670
Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application.
Pérez-Pacheco Y, Tylkowski B, García-Valls R. · · 2025 · cited 12× · PMID 39860124 · DOI 10.3390/molecules30020252

Verify or expand the search:

Other recruiting trials for Necrotic Pulp

Currently open trials in the same condition.

NCT07310212 — Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques · NA · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03588351 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 17 July 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03588351.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing