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NCT03571490
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Laparoscopic Hand-assisted Nephrectomy and Robot Assisted Partiel Nephrectomy
Phase 4 trial testing Ropivacaine in Postoperative Pain in 50 participants. Completed in 24 June 2019.
24 June 2019
Quick facts
| Lead sponsor | Zealand University Hospital |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 26 June 2018 |
| Primary completion | 24 June 2019 |
| Estimated completion | 24 June 2019 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Ropivacaine (ROPIVACAINE) — full drug profile →
- Saline
Conditions studied
- Postoperative Pain — all drugs for Postoperative Pain →
- Ultrasound Guided Transmuscular Quadratus Lumborum Block — all drugs for Ultrasound Guided Transmuscular Quadratus Lumborum Block →
Sponsor
Zealand University Hospital
Who can join
18 and older, any sex, with Postoperative Pain or Ultrasound Guided Transmuscular Quadratus Lumborum Block. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients with kidney cancer often undergo hand-assisted laparoscopic nephrectomy or Robot assisted partiel nephrectomy. The investigators performed a one-year retrospective study. the sudy revealed that 67% of the patients needed substantial amounts of opioids for postoperative pain management (PPM) in recovery despite a multimodal analgesic regime. In a prospective pilot study including ten laparoscopic hand-assisted nephrectomy, with severe postoperative pain the investigators found that bilateral Ultrasound-guided (USG) transmuscular quadratus lumborum (TQL) block substantially reduced pain and opioid consumption. This study aims to evaluate the effect on PPM of a bilateral USG TQL block compared to placebo.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Transmuscular quadratus lumborum block reduces opioid consumption and prolongs time to first opioid demand after laparoscopic nephrectomy.
Dam M, Hansen C, Poulsen TD, Azawi NH, et al · · 2021 · cited 64× · PMID 33106280 · DOI 10.1136/rapm-2020-101745
Verify or expand the search:
- PubMed search for NCT03571490
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03571490 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zealand University Hospital
- Last refreshed: 19 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03571490.
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